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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gad1tm1.1Bgc
targeted mutation 1.1, Brian G Condie
MGI:4442416
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gad1tm1.1Bgc/Gad1tm1.1Bgc involves: 129S6/SvEvTac MGI:4442418
cn2
 		Gad1tm1.1Bgc/Gad1tm1Rpa
Tg(Nes-cre)1Kln/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:4442419


Genotype
MGI:4442418
hm1
Allelic
Composition		 Gad1tm1.1Bgc/Gad1tm1.1Bgc
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad1tm1.1Bgc mutation (1 available); any Gad1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Umbilical hernia in Gad1tm1.1Bgc/Gad1tm1.1Bgc mice

craniofacial
cleft secondary palate ( J:158888 )
• at P0
• injection of pregnant dams with muscimol (a GABA agonist) partially rescues the cleft palate phenotype
failure of palatal shelf elevation ( J:158888 )
• at E14.5
• however, in culture palatal explants are able to undergo elevation and fusion

embryo
umbilical hernia ( J:158888 )
• umbilical hernia is seen in most (85%) pups at P0

digestive/alimentary system
cleft secondary palate ( J:158888 )
• at P0
• injection of pregnant dams with muscimol (a GABA agonist) partially rescues the cleft palate phenotype
failure of palatal shelf elevation ( J:158888 )
• at E14.5
• however, in culture palatal explants are able to undergo elevation and fusion

growth/size/body
cleft secondary palate ( J:158888 )
• at P0
• injection of pregnant dams with muscimol (a GABA agonist) partially rescues the cleft palate phenotype
failure of palatal shelf elevation ( J:158888 )
• at E14.5
• however, in culture palatal explants are able to undergo elevation and fusion




Genotype
MGI:4442419
cn2
Allelic
Composition		 Gad1tm1.1Bgc/Gad1tm1Rpa
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad1tm1.1Bgc mutation (1 available); any Gad1 mutation (65 available)
Gad1tm1Rpa mutation (1 available); any Gad1 mutation (65 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft secondary palate ( J:158888 )
• at E17.5 in 9 of 11 mice

embryo
umbilical hernia ( J:158888 )
• umbilical hernia is seen at E17.5 in 6 of 11 mice

digestive/alimentary system
cleft secondary palate ( J:158888 )
• at E17.5 in 9 of 11 mice

growth/size/body
cleft secondary palate ( J:158888 )
• at E17.5 in 9 of 11 mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory