About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gad1tm1.1Bgc
targeted mutation 1.1, Brian G Condie
MGI:4442416
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gad1tm1.1Bgc/Gad1tm1.1Bgc involves: 129S6/SvEvTac MGI:4442418
cn2
 		Gad1tm1.1Bgc/Gad1tm1Rpa
Tg(Nes-cre)1Kln/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:4442419


Genotype
MGI:4442418
hm1
Allelic
Composition		 Gad1tm1.1Bgc/Gad1tm1.1Bgc
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad1tm1.1Bgc mutation (1 available); any Gad1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Umbilical hernia in Gad1tm1.1Bgc/Gad1tm1.1Bgc mice

craniofacial
cleft secondary palate ( J:158888 )
• at P0
• injection of pregnant dams with muscimol (a GABA agonist) partially rescues the cleft palate phenotype
failure of palatal shelf elevation ( J:158888 )
• at E14.5
• however, in culture palatal explants are able to undergo elevation and fusion

embryo
umbilical hernia ( J:158888 )
• umbilical hernia is seen in most (85%) pups at P0

digestive/alimentary system
cleft secondary palate ( J:158888 )
• at P0
• injection of pregnant dams with muscimol (a GABA agonist) partially rescues the cleft palate phenotype
failure of palatal shelf elevation ( J:158888 )
• at E14.5
• however, in culture palatal explants are able to undergo elevation and fusion

growth/size/body
cleft secondary palate ( J:158888 )
• at P0
• injection of pregnant dams with muscimol (a GABA agonist) partially rescues the cleft palate phenotype
failure of palatal shelf elevation ( J:158888 )
• at E14.5
• however, in culture palatal explants are able to undergo elevation and fusion




Genotype
MGI:4442419
cn2
Allelic
Composition		 Gad1tm1.1Bgc/Gad1tm1Rpa
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad1tm1.1Bgc mutation (1 available); any Gad1 mutation (65 available)
Gad1tm1Rpa mutation (1 available); any Gad1 mutation (65 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft secondary palate ( J:158888 )
• at E17.5 in 9 of 11 mice

embryo
umbilical hernia ( J:158888 )
• umbilical hernia is seen at E17.5 in 6 of 11 mice

digestive/alimentary system
cleft secondary palate ( J:158888 )
• at E17.5 in 9 of 11 mice

growth/size/body
cleft secondary palate ( J:158888 )
• at E17.5 in 9 of 11 mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory