Phenotypes associated with this allele

• Allele Symbol: Mboat4^tm1Vlcg
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4442482
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mboat4^tm1Vlcg/Mboat4^tm1Vlcg	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac	MGI:4442488

Genotype
MGI:4442488

hm1

• Allelic Composition: Mboat4^tm1Vlcg/Mboat4^tm1Vlcg
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:159327 )

• after 7 days on a calorie restricted diet (40% of normal consumption) mice are lethargic and nearly moribund

homeostasis/metabolism

decreased circulating glucose level ( J:159327 )

• in calorie restricted mice, blood glucose levels continue to decrease for 7 days reaching a low of 12 mg/dl while in wild-type mice blood glucose levels stabilize after 2 days

• in calorie restricted mice, infusion of ghrelin or growth hormone normalizes glucose levels so that they are similar to those in diet matched wild-type mice

decreased circulating ghrelin level ( J:159327 )

• ghrelin is not detectable in the plasma in either ad libitum fed or calorie restricted mice

decreased circulating growth hormone level ( J:159327 )

• in calorie restricted mice levels are 2 fold lower than in diet matched wild-type controls

• however, levels are similar to wild-type in ad libitum fed mice

improved glucose tolerance ( J:159327 )

• modestly enhanced with a lower glucose levels and a slight but significant increase in plasma insulin at the 30 min time point

• high fat diet feeding glucose tolerance worsens but glucose levels are still lower and plasma insulin levels are higher than in diet matched wild-type