All Phenotypes Fbln5<tm1.1Hiya> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fbln5^tm1.1Hiya
targeted mutation 1.1, Hiromi Yanagisawa
MGI:4442490

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbln5^tm1.1Hiya/Fbln5^tm1.1Hiya	involves: 129S6/SvEvTac	MGI:4442505

Allelic Composition	Fbln5^tm1.1Hiya/Fbln5^tm1.1Hiya
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbln5^tm1.1Hiya mutation (0 available); any Fbln5 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased angiogenesis ( J:159246 )

• tumors from pancreatic carcinoma cell line Pan02 injected subcutaneously exhibit reduced angiogenesis compared with tumors from cells injected into wild-type mice

• however, treatment with antioxidant rescues tumor angiogenesis

neoplasm

decreased tumor growth/size ( J:159246 )

• tumors from pancreatic carcinoma cell line Pan02 injected subcutaneously exhibit reduced size, growth, and angiogenesis and increased reactive oxygen species compared with tumors from cells injected into wild-type mice

• however, treatment with antioxidant rescues tumor angiogenesis and growth

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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