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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ugcgtm4Rlp
targeted mutation 4, Richard L Proia
MGI:4442647
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ugcgtm4Rlp/Ugcgtm4Rlp involves: 129S6/SvEvTac * C57BL/6 MGI:4442807
cn2
 		Ugcgtm4Rlp/Ugcgtm4Rlp
Tg(Nes-cre)1Kln/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:4442808
cn3
 		Ugcgtm1Rlp/Ugcgtm4Rlp
Tg(Nes-cre)1Kln/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:4442809


Genotype
MGI:4442807
hm1
Allelic
Composition		 Ugcgtm4Rlp/Ugcgtm4Rlp
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ugcgtm4Rlp mutation (1 available); any Ugcg mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:103415 )
• mice are viable




Genotype
MGI:4442808
cn2
Allelic
Composition		 Ugcgtm4Rlp/Ugcgtm4Rlp
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Ugcgtm4Rlp mutation (1 available); any Ugcg mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
limb grasping ( J:103415 )
• at 6 months
abnormal gait ( J:103415 )
• aged mice exhibit a labored gait unlike wild-type mice

nervous system
Purkinje cell degeneration ( J:103415 )
• severe at 9 months
• increases with age




Genotype
MGI:4442809
cn3
Allelic
Composition		 Ugcgtm1Rlp/Ugcgtm4Rlp
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Ugcgtm1Rlp mutation (0 available); any Ugcg mutation (87 available)
Ugcgtm4Rlp mutation (1 available); any Ugcg mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
limb grasping ( J:103415 )
• at 6 months
abnormal gait ( J:103415 )
• aged mice exhibit a labored gait unlike wild-type mice

nervous system
Purkinje cell degeneration ( J:103415 )
• severe at 9 months
• increases with age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory