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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp73tm2Mak
targeted mutation 2, Tak Mak
MGI:4442798
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp73tm2Mak/Trp73tm2Mak either: B6.129P2-Trp73tm2Mak or (involves: 129P2/OlaHsd * C57BL/6J) MGI:4442799
cx2
 		Trp53tm1Brd/Trp53tm1Brd
Trp73tm2Mak/Trp73tm2Mak 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J MGI:4442800
cx3
 		Atmtm1Pmc/Atmtm1Pmc
Trp73tm2Mak/Trp73tm2Mak 		involves: 129P2/OlaHsd * C57BL/6J MGI:4442801


Genotype
MGI:4442799
hm1
Allelic
Composition		 Trp73tm2Mak/Trp73tm2Mak
Genetic
Background		 either: B6.129P2-Trp73tm2Mak or (involves: 129P2/OlaHsd * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp73tm2Mak mutation (3 available); any Trp73 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:157905 )
• the gender ratio was slightly but significantly skewed at birth with fewer females being born than males

nervous system
abnormal cerebral cortex morphology ( J:157905 )
• neuronal density is significantly reduced in the motor cortex at 10 and 26-27 months of age
• by 26-27 mo of age, motor cortex thickness is reduced significantly
decreased neuron number ( J:157905 )
• neuronal density is significantly reduced in the motor cortex at 10 and 26-27 months of age
neurodegeneration ( J:157905 )
• signs of mild neurodegeneration are seen such as an increase in the number of condensed cells at 10 months of age

hematopoietic system
increased thymocyte apoptosis ( J:157905 )
• increased apoptosis in response to DNA damaging agents (cisplatin, doxorubicin, etoposide and gamma-irradiation)

immune system
increased thymocyte apoptosis ( J:157905 )
• increased apoptosis in response to DNA damaging agents (cisplatin, doxorubicin, etoposide and gamma-irradiation)

homeostasis/metabolism
increased physiological sensitivity to xenobiotic ( J:157905 )
• both MEFs and thymocytes show increased sensitivity to DNA damaging agents including, cisplatin, doxorubicin and etoposide

cellular
increased sensitivity to induced cell death ( J:157905 )
• both MEFs and thymocytes show increased sensitivity to DNA damaging agents including, cisplatin, doxorubicin and etoposide
• however, no difference in the apoptotic response to UV treatment, TNFalpha treatment, or IL-2 withdrawal is detected
increased cellular sensitivity to gamma-irradiation ( J:157905 )
• both MEFs and thymocytes show increased sensitivity to gamma irradiation induced apoptosis
increased thymocyte apoptosis ( J:157905 )
• increased apoptosis in response to DNA damaging agents (cisplatin, doxorubicin, etoposide and gamma-irradiation)

endocrine/exocrine glands
increased thymocyte apoptosis ( J:157905 )
• increased apoptosis in response to DNA damaging agents (cisplatin, doxorubicin, etoposide and gamma-irradiation)




Genotype
MGI:4442800
cx2
Allelic
Composition		 Trp53tm1Brd/Trp53tm1Brd
Trp73tm2Mak/Trp73tm2Mak
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Brd mutation (5 available); any Trp53 mutation (240 available)
Trp73tm2Mak mutation (3 available); any Trp73 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte apoptosis ( J:157905 )
• the increased apoptosis in response to DNA damaging agents is reversed compared to mice homozygous for Trp73 tm2Mak alone, returning it to wild-type levels

immune system
decreased thymocyte apoptosis ( J:157905 )
• the increased apoptosis in response to DNA damaging agents is reversed compared to mice homozygous for Trp73 tm2Mak alone, returning it to wild-type levels

cellular
decreased cellular sensitivity to gamma-irradiation ( J:157905 )
• the increased apoptosis in response to gamma-irradiation is reversed compared to mice homozygous for Trp73 tm2Mak alone, returning it to wild-type levels
decreased thymocyte apoptosis ( J:157905 )
• the increased apoptosis in response to DNA damaging agents is reversed compared to mice homozygous for Trp73 tm2Mak alone, returning it to wild-type levels

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:157905 )
• the increased apoptosis in response to DNA damaging agents is reversed compared to mice homozygous for Trp73 tm2Mak alone, returning it to wild-type levels




Genotype
MGI:4442801
cx3
Allelic
Composition		 Atmtm1Pmc/Atmtm1Pmc
Trp73tm2Mak/Trp73tm2Mak
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Pmc mutation (0 available); any Atm mutation (170 available)
Trp73tm2Mak mutation (3 available); any Trp73 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte apoptosis ( J:157905 )
• the increased apoptosis in response to DNA damaging agents is reversed compared to Trp73 tm2Mak single mutants, with cells showing reisistance to apoptosis similar to that in Atmtm1Pmc single mutants

immune system
decreased thymocyte apoptosis ( J:157905 )
• the increased apoptosis in response to DNA damaging agents is reversed compared to Trp73 tm2Mak single mutants, with cells showing reisistance to apoptosis similar to that in Atmtm1Pmc single mutants

cellular
decreased cellular sensitivity to gamma-irradiation ( J:157905 )
• the increased thymocyte apoptosis in response to gamma-irradiation is reversed compared to mice homozygous for Trp73 tm2Mak single mutants, with cells showing reisistance to apoptosis similar to that in Atmtm1Pmc single mutants
decreased thymocyte apoptosis ( J:157905 )
• the increased apoptosis in response to DNA damaging agents is reversed compared to Trp73 tm2Mak single mutants, with cells showing reisistance to apoptosis similar to that in Atmtm1Pmc single mutants

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:157905 )
• the increased apoptosis in response to DNA damaging agents is reversed compared to Trp73 tm2Mak single mutants, with cells showing reisistance to apoptosis similar to that in Atmtm1Pmc single mutants




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory