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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpr149tm1.1Zuk
targeted mutation 1.1, Martin M Matzuk
MGI:4442841
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpr149tm1.1Zuk/Gpr149tm1.1Zuk involves: 129S7/SvEvBrd * C57BL/6J * FVB/N MGI:4442853
ht2
 		Gpr149tm1.1Zuk/Gpr149+ involves: 129S7/SvEvBrd * C57BL/6J * FVB/N MGI:4442854


Genotype
MGI:4442853
hm1
Allelic
Composition		 Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr149tm1.1Zuk mutation (0 available); any Gpr149 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased secondary ovarian follicle number ( J:158302 )
• the number of preantral follicles is greater than in wild-type mice
increased tertiary ovarian follicle number ( J:158302 )
• the number of antral follicles is greater than in wild-type mice
abnormal ovarian folliculogenesis ( J:158302 )
• the number of cumulus-oocyte-complexes recovered from PMSG (pregnant mare serum gonadotropin)-treated antrals is slightly greater than from similarly treated wild-type follicles
increased ovulation rate ( J:158302 )
• spontaneous ovulation is greater than in wild-type mice
increased superovulation rate ( J:158302 )
• superovulated females produce more oocytes than similarly treated wild-type mice
abnormal estrous cycle ( J:158302 )
• the time between estrus is decreased compared to in wild-type mice
increased litter size ( J:158302 )
• females show a modest but significant increase in average litter size relative to control females
enhanced female fertility ( J:158302 )
• female mice exhibit increased fertility with increased litter size and number of litters per month compared with wild-type mice
• however, time to first litter is normal
abnormal fertilization ( J:158302 )
• fertilization of oocytes from superovulated immature females is greater than for oocytes from similarly treated wild-type mice

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:158302 )
N
• female mice exhibit normal levels of follicle stimulation hormone and luteinizing hormone

endocrine/exocrine glands
increased secondary ovarian follicle number ( J:158302 )
• the number of preantral follicles is greater than in wild-type mice
increased tertiary ovarian follicle number ( J:158302 )
• the number of antral follicles is greater than in wild-type mice
abnormal ovarian folliculogenesis ( J:158302 )
• the number of cumulus-oocyte-complexes recovered from PMSG (pregnant mare serum gonadotropin)-treated antrals is slightly greater than from similarly treated wild-type follicles




Genotype
MGI:4442854
ht2
Allelic
Composition		 Gpr149tm1.1Zuk/Gpr149+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr149tm1.1Zuk mutation (0 available); any Gpr149 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased superovulation rate ( J:158302 )
• superovulated females produce more oocytes than similarly treated wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory