Phenotypes associated with this allele

• Allele Symbol: Podxl^tm1Parl
• Allele Name: targeted mutation 1, Roberto Parrilla
• Allele ID: MGI:4442892
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Podxl^tm1Parl/Podxl^tm1Parl Podxl2^tm1c(EUCOMM)Wtsi/Podxl2^tm1c(EUCOMM)Wtsi Tg(Pax3-cre)1Joe/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * SJL	MGI:6711207
cn2	Podxl^tm1Parl/Podxl^+ Tg(Mylpf-cre)3Kraj/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N	MGI:4442893
cn3	Podxl^tm1Parl/Podxl^tm1Parl Tg(Mylpf-cre)3Kraj/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N	MGI:4442896
cn4	Podxl^tm1Parl/Podxl^tm1Parl Podxl2^tm1c(EUCOMM)Wtsi/Podxl2^tm1c(EUCOMM)Wtsi Six2^tm1(tTA,tetO-EGFP/cre)Amc/Six2^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:6711208

Genotype
MGI:6711207

cn1

• Allelic Composition: Podxl^tm1Parl/Podxl^tm1Parl; Podxl2^{tm1c(EUCOMM)Wtsi}/Podxl2^{tm1c(EUCOMM)Wtsi}; Tg(Pax3-cre)1Joe/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * SJL
• Cell Lines: EPD0647_7_C06

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:240523 )

N • mice show no delay in timely lumen formation in developing epithelial tubules in the kidney at E14.5

Genotype
MGI:4442893

cn2

• Allelic Composition: Podxl^tm1Parl/Podxl⁺; Tg(Mylpf-cre)3Kraj/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N

normal phenotype

no abnormal phenotype detected ( J:158322 )

Genotype
MGI:4442896

cn3

• Allelic Composition: Podxl^tm1Parl/Podxl^tm1Parl; Tg(Mylpf-cre)3Kraj/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N

nervous system

enlarged brain ventricles ( J:158322 )

• the ventricular spaces were enlarged

cardiovascular system

abnormal carotid artery morphology ( J:158322 )

• the carotid arteries are thicker than the wild type control

abnormal capillary morphology ( J:158322 )

• increased number of capillaries lining the intraventricular spaces

Genotype
MGI:6711208

cn4

• Allelic Composition: Podxl^tm1Parl/Podxl^tm1Parl; Podxl2^{tm1c(EUCOMM)Wtsi}/Podxl2^{tm1c(EUCOMM)Wtsi}; Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

mortality/aging

neonatal lethality, complete penetrance ( J:240523 )

• mice die in the neonatal period

renal/urinary system

renal/urinary system phenotype ( J:240523 )

N • mice show no obvious defects in nephron lumen formation or luminal continuity indicating normal early stages of nephrogenesis