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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Blnkm1Btlr
mutation 1, Bruce Beutler
MGI:4442912
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Blnkm1Btlr/Blnkm1Btlr C57BL/6J-Blnkm1Btlr MGI:4442913
hm2
 		Blnkm1Btlr/Blnkm1Btlr involves: C57BL/6J MGI:5429183


Genotype
MGI:4442913
hm1
Allelic
Composition		 Blnkm1Btlr/Blnkm1Btlr
Genetic
Background		 C57BL/6J-Blnkm1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnkm1Btlr mutation (1 available); any Blnk mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:159439 )
• the peripheral B cells of mutant mice exhibit an immature phenotype
decreased mature B cell number ( J:159439 )
• mutant mice have reduced numbers of peripheral B cells
decreased IgG level ( J:159439 )
• mutant mice exhibit a reduced T cell dependent IgG response to model antigens
decreased IgM level ( J:159439 )
• mutant mice exhibit a reduced T cell independent IgM response to haptenated Ficoll

immune system
arrested B cell differentiation ( J:159439 )
• the peripheral B cells of mutant mice exhibit an immature phenotype
decreased mature B cell number ( J:159439 )
• mutant mice have reduced numbers of peripheral B cells
decreased IgG level ( J:159439 )
• mutant mice exhibit a reduced T cell dependent IgG response to model antigens
decreased IgM level ( J:159439 )
• mutant mice exhibit a reduced T cell independent IgM response to haptenated Ficoll




Genotype
MGI:5429183
hm2
Allelic
Composition		 Blnkm1Btlr/Blnkm1Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnkm1Btlr mutation (1 available); any Blnk mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:185495 )
N
• mice exhibit a normal response to NP-Ficoll and recombinant Semliki Forest virus (SFV) encoded antigen
decreased IgM level ( J:185495 )
• following NP-Ficoll immunization

hematopoietic system
decreased IgM level ( J:185495 )
• following NP-Ficoll immunization




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory