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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pclotm3.2Sud
targeted mutation 3.2, Thomas C Sudhof
MGI:4442914
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pclotm3.2Sud/Pclotm3.2Sud involves: 129S1/Sv * 129X1/SvJ MGI:4442918


Genotype
MGI:4442918
hm1
Allelic
Composition
Pclotm3.2Sud/Pclotm3.2Sud
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pclotm3.2Sud mutation (0 available); any Pclo mutation (267 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 20% of mice die by P60
• 20% of mice die by P60

nervous system
N
• regardless of treatment with an shRNA Bsn lentivirus, cultured neurons exhibit normal excitatory and inhibitory synaptic transmission, short-term synaptic plasticity, and ready releasable pool
• following treatment with an shRNA Bsn lentivirus, neurons exhibit decreased synaptic vesicle clustering, number of vesicles in nerve terminals, overall density of vesicles per terminal area, overall vesicle numbers, the number of vesicles close to the active zone, and docked at the active zone compared to in wild-type cells
• following treatment with an shRNA Bsn lentivirus, neurons exhibit an increase in postsynaptic density compared with wild-type cells
• however, mice exhibit normal size of presynaptic terminals and synaptic vesicles
• during a 15-Hz stimulus train, mice exhibit a small increase in depression at later stages compared with similarly treated wild-type mice
• however, mice exhibit normal paired-pulse facilitation, post-tetanic potentiation, and short-term plasticity is normal

growth/size/body





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory