Phenotypes associated with this allele

• Allele Symbol: Mapt^{tm2.1(RHOA*)Klt}
• Allele Name: targeted mutation 2.1, Kerry Lee Tucker
• Allele ID: MGI:4442945
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mapt^tm2.1(RHOA*)Klt/Mapt^+	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:4442966

Genotype
MGI:4442966

ht1

• Allelic Composition: Mapt^{tm2.1(RHOA*)Klt}/Mapt⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:159220 )

N • mice exhibit normal cortical anatomy and neuronal migration and cell type specification of cortical neuron

decreased neuron apoptosis ( J:159220 )

• in the somatosensory cortex at P5

abnormal somatosensory cortex morphology ( J:159220 )

• at P24, mice exhibit an increase in number and density of neurons in the somatosensory neurons compared with wild-type mice

• however, the density of interneurons in the somatosensory cortex is normal

increased neuron number ( J:159220 )

• at P24, mice exhibit an increase in number and density of neurons in the somatosensory neurons compared with wild-type mice

cellular

decreased neuron apoptosis ( J:159220 )

• in the somatosensory cortex at P5