Phenotypes associated with this allele

• Allele Symbol: Camk4^tm1Tsmi
• Allele Name: targeted mutation 1, Tsuyoshi Miyakawa
• Allele ID: MGI:4442999
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camk4^tm1Tsmi/Camk4^tm1Tsmi	B6N.129S-Camk4^tm1Tsmi	MGI:4443001

Genotype
MGI:4443001

hm1

• Allelic Composition: Camk4^tm1Tsmi/Camk4^tm1Tsmi
• Genetic Background: B6N.129S-Camk4^tm1Tsmi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:158693 )

• slight decrease in body weight

behavior/neurological

behavior/neurological phenotype ( J:158693 )

N • unlike contextual or cued conditioning behavior, no defect is detected in passive avoidance tests

abnormal behavior ( J:158693 )

• travel a greater distance in response to footshock

• however, response in the hot plate assay is similar to controls

impaired contextual conditioning behavior ( J:158693 )

• significantly less contextual freezing at 28 days after training

• significantly lower freezing during the pre-tone period at 28 days after training

impaired cued conditioning behavior ( J:158693 )

• significantly less freezing behavior in response to the conditioned tone

decreased anxiety-related response ( J:158693 )

• in the first 3 min of the light/dark transition test, mice travel significantly longer distances in the light chamber and spend more time in the light chamber suggesting a mild decrease in anxiety like behavior

• spend significantly less time in the closed arms and significantly more time in the center area