Phenotypes associated with this allele

• Allele Symbol: Mirc32^tm1Gcon
• Allele Name: targeted mutation 1, Gianluigi Condorelli
• Allele ID: MGI:4443000
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mirc32^tm1Gcon/Mirc32^tm1Gcon	involves: 129S1/Sv * 129X1/SvJ	MGI:4443313

Genotype
MGI:4443313

hm1

• Allelic Composition: Mirc32^tm1Gcon/Mirc32^tm1Gcon
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aorta tunica intima morphology ( J:159593 )

• unlike in wild-type mice, small accumulations of vascular smooth muscle cells occur within the intimal layer of the aorta

abnormal aorta tunica media morphology ( J:159593 )

• medial thickness and media to lumen area ratio are decreased compared to in wild-type mice

abnormal aorta smooth muscle morphology ( J:159593 )

• aortic vascular smooth muscle cells exhibit dilated rough endoplasmic reticulum and extended areas of extracellular matrix degradation compared with wild-type cells

• vascular smooth muscle cells are dedifferentiated, as determined by marker expression, compared with wild-type cells

decreased systemic arterial systolic blood pressure ( J:159593 )

• angiotensin II treated mice exhibit a reduced increase in systolic pressure compared with similarly treated wild-type mice

abnormal vascular smooth muscle physiology ( J:159593 )

• in culture vascular smooth muscle cells from the aorta exhibit increased migration towards PDGF compared with similarly treated wild-type cell

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:159593 )

• angiotensin II treated mice exhibit a reduced increase in systolic pressure compared with similarly treated wild-type mice

muscle

abnormal aorta smooth muscle morphology ( J:159593 )

• aortic vascular smooth muscle cells exhibit dilated rough endoplasmic reticulum and extended areas of extracellular matrix degradation compared with wild-type cells

• vascular smooth muscle cells are dedifferentiated, as determined by marker expression, compared with wild-type cells

abnormal vascular smooth muscle physiology ( J:159593 )

• in culture vascular smooth muscle cells from the aorta exhibit increased migration towards PDGF compared with similarly treated wild-type cell