All Phenotypes Sall1<tm5(cre/ERT2)Ryn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sall1^{tm5(cre/ERT2)Ryn}
targeted mutation 5, Ryuichi Nishinakamura
MGI:4443031

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sall1^{tm5(cre/ERT2)Ryn}/Sall1^tm4.1Ryn	involves: 129P2/OlaHsd	MGI:4818961

Allelic Composition	Sall1^{tm5(cre/ERT2)Ryn}/Sall1^tm4.1Ryn
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall1^tm4.1Ryn mutation (2 available); any Sall1 mutation (78 available)
Sall1^{tm5(cre/ERT2)Ryn} mutation (0 available); any Sall1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:159446 )

• mutants do not survive after birth with tamoxifen treatment on E12.5

renal/urinary system

abnormal kidney morphology ( J:159446 )

• tubular structures are reduced at E14.5

small kidney ( J:159446 )

• with i.p. tamoxifen delivery to pregnant dams on E12.5, kidney size is significantly reduced at E18.5

abnormal renal tubule morphology ( J:159446 )

• numbers of proximal and distale tubules are significantly reduced compared to controls, but glomerular development is not significantly affected

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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