Phenotypes associated with this allele

• Allele Symbol: Myh10^tm7Rsad
• Allele Name: targeted mutation 7, Robert S Adelstein
• Allele ID: MGI:4443039
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Myh10^tm7Rsad/Myh10^tm7Rsad Tg(Nes-cre)1Wme/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA	MGI:4946094
cn2	Myh10^tm7Rsad/Myh10^tm7Rsad Tg(Myh6-cre)2182Mds/0	involves: 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:4946095

Genotype
MGI:4946094

cn1

• Allelic Composition: Myh10^tm7Rsad/Myh10^tm7Rsad; Tg(Nes-cre)1Wme/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:170148 )

• mice die between P12 and P22

nervous system

abnormal cerebellum development ( J:170148 )

• underdeveloped

hydrocephaly ( J:170148 )

• severe

enlarged lateral ventricles ( J:170148 )

thin cerebral cortex ( J:170148 )

• paper-thin with the absence of most brain cortical tissue

abnormal spinal cord central canal morphology ( J:170148 )

• at P7, the spinal canal is ablated unlike in wild-type mice

behavior/neurological

abnormal locomotor behavior ( J:170148 )

cardiovascular system

cardiovascular system phenotype ( J:170148 )

N • unlike null mice, cardiac development is normal

Genotype
MGI:4946095

cn2

• Allelic Composition: Myh10^tm7Rsad/Myh10^tm7Rsad; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

cardiovascular system

abnormal intercalated disk morphology ( J:170148 )

• widened and distorted in 4 of 5 mice

increased myocardial fiber size ( J:170148 )

• at P0, 6 months, and 10 months with abnormal nuclei

ventricular septal defect ( J:170148 )

• in 2 of 9 mice without double outlet heart right ventricle

cardiac interstitial fibrosis ( J:170148 )

• at 10 months

decreased cardiac muscle contractility ( J:170148 )

• at 10 months

abnormal impulse conducting system conduction ( J:170148 )

cardiomyopathy ( J:170148 )

• at 10 months, mice exhibit increased left ventricular internal diameter at the end of systole and decreased fractional shortening with abnormal intercalated disc compared with wild-type mice

heart inflammation ( J:170148 )

• at 6 and 10 months

homeostasis/metabolism

abnormal atrial thrombosis ( J:170148 )

• in the atrium of 2 in 8 mice at 10 months

immune system

heart inflammation ( J:170148 )

• at 6 and 10 months

muscle

abnormal intercalated disk morphology ( J:170148 )

• widened and distorted in 4 of 5 mice

increased myocardial fiber size ( J:170148 )

• at P0, 6 months, and 10 months with abnormal nuclei

decreased cardiac muscle contractility ( J:170148 )

• at 10 months

cardiomyopathy ( J:170148 )

• at 10 months, mice exhibit increased left ventricular internal diameter at the end of systole and decreased fractional shortening with abnormal intercalated disc compared with wild-type mice

increased cardiomyocyte apoptosis ( J:170148 )

cellular

cardiac interstitial fibrosis ( J:170148 )

• at 10 months

increased cardiomyocyte apoptosis ( J:170148 )