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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tra2btm1.2Bwir
targeted mutation 1.2, Brunhilde Wirth
MGI:4450921
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tra2btm1.2Bwir/Tra2btm1.2Bwir involves: 129S4/SvJae * C57BL/6 * C57BL/6N MGI:4450951


Genotype
MGI:4450951
hm1
Allelic
Composition		 Tra2btm1.2Bwir/Tra2btm1.2Bwir
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tra2btm1.2Bwir mutation (0 available); any Tra2b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:159448 )
• high numbers of resorbed embryos at E10.5

cardiovascular system
abnormal vasculogenesis ( J:159448 )
• no vascularization at E7.5

embryo
abnormal allantois morphology ( J:159448 )
• sometimes identified in E8.5 embryos

growth/size/body
decreased embryo size ( J:159448 )
• at E7.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory