Analysis Tools
homeostasis/metabolism
| N |
• normal ambient blood glucose level
• normal body weight and food intake on regular chow
• normal fatty acid oxidation rates in ex vivo soleus muscle
• normal malonyl CoA levels in skeletal muscle
• normal serum triglycerides, nonesterified fatty acids and beta-hydroxybutyrate concentrations
• normal weight gain after metabolically challenged with 11 weeks of high fat (58%) feeding or 36 weeks of high fat (45%) feeding
• normal ambient glucose or insulin levels metabolically challenged with 11 weeks of high fat (58%) feeding or 36 weeks of high fat (45%) feeding
|
|
• slightly increased ambient blood insulin levels
• unaffected response to an intraperitoneal glucose load
|
|
• reduced total acetyl CoA carboxylase activity (40% compared to controls) in skeletal muscle extracts
• decreased malonyl CoA levels (30%) and selectively reduced subsets of fatty acyl CoAs (C16:1 and C18:1) in heart
|
|
• a slight increase in oxygen consumption during the dark cycle
• a nonsignificant trend toward increased oxygen consumption in the light cycle
|
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• decrease in respiratory exchange ratio during both the dark and light cycles
|
cardiovascular system
small heart
(
J:159285
)
|
• reduced heart size
|
behavior/neurological
|
• increased physical activity in both the dark and light cycles as compared to controls
|
