Phenotypes associated with this allele

• Allele Symbol: Itprip^tm1.1Snyd
• Allele Name: targeted mutation 1.1, Solomon Snyder
• Allele ID: MGI:4450972
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itprip^tm1.1Snyd/Itprip^tm1.1Snyd	involves: C57BL/6	MGI:4450973

Genotype
MGI:4450973

hm1

• Allelic Composition: Itprip^tm1.1Snyd/Itprip^tm1.1Snyd
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:157643 )

• a 35% increase in death-associated protein kinase (DAPK) activity in primary MEFs derived from mutant mice

• mutant mice are normal with no obvious neurological, gross, or developmental alterations

increased sensitivity to induced cell death ( J:157643 )

• in tunicamycin-treated MEFs and in C6-ceramide-induced cell death in hippocampal neurons

homeostasis/metabolism

increased cerebral infarct size ( J:157643 )

• NMDA-induced brain lesions are significantly greater mutant mice

• after MCAO treatment, infarct volume is significantly greater in mutant mice

nervous system

increased cerebral infarct size ( J:157643 )

• NMDA-induced brain lesions are significantly greater mutant mice

• after MCAO treatment, infarct volume is significantly greater in mutant mice