Phenotypes associated with this allele

• Allele Symbol: Slc2a8^tm1.1Asch
• Allele Name: targeted mutation 1.1, Annette Schuermann
• Allele ID: MGI:4450978
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc2a8^tm1.1Asch/Slc2a8^tm1.1Asch	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4454541

Genotype
MGI:4454541

hm1

• Allelic Composition: Slc2a8^tm1.1Asch/Slc2a8^tm1.1Asch
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

asthenozoospermia ( J:159441 )

♂ • the number of motile sperm is reduced compared to in wild-type mice

mortality/aging

preweaning lethality, incomplete penetrance ( J:159441 )

• fewer than expected mice are produced (no time of death or observation given)

reproductive system

reproductive system phenotype ( J:159441 )

N • mice produce normal sized litters and the number and survival rate of spermatozoa are normal

abnormal sperm physiology ( J:159441 )

♂ • spermatozoa exhibit reduced ATP levels and mitochondrial membrane potential compared to in wild-type cells

asthenozoospermia ( J:159441 )

♂ • the number of motile sperm is reduced compared to in wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:159441 )

N • mice exhibit normal plasma glucose, triglyceride, free fatty acid and insulin levels

growth/size/body

growth/size/body region phenotype ( J:159441 )

N • mice exhibit normal body weight and body composition