Phenotypes associated with this allele

• Allele Symbol: Map3k1^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4451248
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map3k1^tm1a(KOMP)Wtsi/Map3k1^tm1a(KOMP)Wtsi	C57BL/6N-Map3k1^tm1a(KOMP)Wtsi/Wtsi	MGI:5631291
ht2	Map3k1^tm1a(KOMP)Wtsi/Map3k1^+	C57BL/6N-Map3k1^tm1a(KOMP)Wtsi/Wtsi	MGI:5706036

Genotype
MGI:5631291

hm1

• Allelic Composition: Map3k1^{tm1a(KOMP)Wtsi}/Map3k1^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Map3k1^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0287_3_A11

Data Sources

IMPC Data for Map3k1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - WTSI

Genotype
MGI:5706036

ht2

• Allelic Composition: Map3k1^{tm1a(KOMP)Wtsi}/Map3k1⁺
• Genetic Background: C57BL/6N-Map3k1^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0287_3_A11

Data Sources

IMPC Data for Map3k1

growth/size/body

increased lean body mass ( J:211773 )

♂

IMPC - WTSI

hematopoietic system

increased red blood cell distribution width ( J:211773 )

♂

IMPC - WTSI

homeostasis/metabolism

decreased circulating fructosamine level ( J:211773 )

♂

IMPC - WTSI

decreased fasting circulating glucose level ( J:211773 )

♂

IMPC - WTSI

increased circulating free fatty acids level ( J:211773 )

♀

IMPC - WTSI

skeleton

increased bone mineral content ( J:211773 )

♂

IMPC - WTSI

vision/eye

abnormal retina morphology ( J:211773 )

♀

IMPC - WTSI