Phenotypes associated with this allele

• Allele Symbol: Sox30^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4451538
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox30^tm1a(KOMP)Wtsi/Sox30^tm1a(KOMP)Wtsi	involves: C57BL/6N	MGI:6115517

Genotype
MGI:6115517

hm1

• Allelic Composition: Sox30^{tm1a(KOMP)Wtsi}/Sox30^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

multinucleated giant male germ cells ( J:255310 )

♂ • multinucleated giant cells are present in the testis cords and are first detected at P21

♂ • multinucleated giant cells often contain more than 4 nuclei

small testis ( J:255310 )

♂ • average length is about 72.4% of wild-type or heterozygous controls

abnormal spermatogenesis ( J:255310 )

♂ • a significant number of haploid germ cells are precociously released

azoospermia ( J:255310 )

♂ • epididymal tubules appear devoid of sperm

abnormal spermatid morphology ( J:255310 )

♂ • Golgi bodies appear smaller and docking of the basal body and attachment of the acrosomal vesical to the nucleus are absent in round spermatids

arrest of spermiogenesis ( J:255310 )

♂ • arrest at the round spermatid stage

♂ • fail to progress beyond step 3 of spermiogenesis

male infertility ( J:255310 )

♂ • males exhibit normal mating behavior but fail to impregnate their partners

♂ • female fertility is normal

cellular

azoospermia ( J:255310 )

♂ • epididymal tubules appear devoid of sperm

abnormal spermatid morphology ( J:255310 )

♂ • Golgi bodies appear smaller and docking of the basal body and attachment of the acrosomal vesical to the nucleus are absent in round spermatids

multinucleated giant male germ cells ( J:255310 )

♂ • multinucleated giant cells are present in the testis cords and are first detected at P21

♂ • multinucleated giant cells often contain more than 4 nuclei

endocrine/exocrine glands

small testis ( J:255310 )

♂ • average length is about 72.4% of wild-type or heterozygous controls