Phenotypes associated with this allele

• Allele Symbol: Traf2^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4452008
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Traf2^tm1a(EUCOMM)Wtsi/Traf2^tm1a(EUCOMM)Wtsi	C57BL/6N-Traf2^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5631638
ht2	Traf2^tm1a(EUCOMM)Wtsi/Traf2^+	C57BL/6N-Traf2^tm1a(EUCOMM)Wtsi/Wtsi	MGI:6263756

Genotype
MGI:5631638

hm1

• Allelic Composition: Traf2^{tm1a(EUCOMM)Wtsi}/Traf2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Traf2^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0521_4_F03

Data Sources

IMPC Data for Traf2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:261316 )

• labyrinth vascular defect at E14.5, with severely reduced complexity of labyrinth vascularization

placenta hemorrhage ( J:261316 )

• hemorrhagic areas/blood pools are seen in the E14.5 placenta

embryo

placenta hemorrhage ( J:261316 )

• hemorrhagic areas/blood pools are seen in the E14.5 placenta

abnormal placenta morphology ( J:261316 )

• reduced cellular density of placenta at E14.5

• fibrotic and/or necrotic areas in the placenta at E14.5

abnormal placental labyrinth vasculature morphology ( J:261316 )

• labyrinth vascular defect at E14.5, with severely reduced complexity of labyrinth vascularization

placenta necrosis ( J:261316 )

• necrotic areas in the placenta at E14.5

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

lethality throughout fetal growth and development, complete penetrance ( J:261316 )

• complete lethality at E14.5

Genotype
MGI:6263756

ht2

• Allelic Composition: Traf2^{tm1a(EUCOMM)Wtsi}/Traf2⁺
• Genetic Background: C57BL/6N-Traf2^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0521_4_F03

Data Sources

IMPC Data for Traf2

hematopoietic system

decreased alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

increased circulating chloride level ( J:211773 )

IMPC - WTSI

immune system

decreased alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI