immune system
N |
• CD4+ T cells activated in vitro with anti-CD3/CD28 antibodies and exposed to a cre adenovirus exhibit normal CD4 expression
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Allele Symbol Allele Name Allele ID |
Rr94tm3.1Litt targeted mutation 3.1, Dan R Littman MGI:4452050 |
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Summary |
5 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• CD4+ T cells activated in vitro with anti-CD3/CD28 antibodies and exposed to a cre adenovirus exhibit normal CD4 expression
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|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit the same phenotype as Cd4tm3.2Litt homozygotes
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• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
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• mice exhibit a decreased in CD4 expression in lamina propria lin-c-kit+CD127+ cells compared to in wild-type mice
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• in the thymus and spleen
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• mice exhibit the same phenotype as Cd4tm3.2Litt homozygotes
|
• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
|
• mice exhibit a decreased in CD4 expression in lamina propria lin-c-kit+CD127+ cells compared to in wild-type mice
|
• in the thymus and spleen
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit the same phenotype as Cd4tm3.2Litt homozygotes
|
• in the thymus
|
• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
|
• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice
|
• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice
|
• mice exhibit the same phenotype as Cd4tm3.2Litt homozygotes
|
• in the thymus
|
• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
|
• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice
|
• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit a population of CD4lo8+ double positive T cells in the mature thymocyte compartment and the spleen unlike in wild-type mice
|
• in the thymus
|
• in the spleen
|
• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
|
• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice
|
• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice
|
• mice exhibit a population of CD4lo8+ double positive T cells in the mature thymocyte compartment and the spleen unlike in wild-type mice
|
• in the thymus
|
• in the spleen
|
• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice
|
• the percentage of CD4 single positive cell in the thymus and spleen is decreased compared to in wild-type mice
|
• the percentage of CD8 single positive cell in the thymus and spleen is increased compared to in wild-type mice
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice exhibit normal CD4 expression during thymocyte development, in mature T cells, and splenic dendritic cells
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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