About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sfntm1Mul
targeted mutation 1, William J Muller
MGI:4452136
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sfntm1Mul/Sfntm1Mul involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:4452137
cn2
 		Sfntm1Mul/Sfntm1Mul
Tg(MMTV-cre)7Mul/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:4452139


Genotype
MGI:4452137
hm1
Allelic
Composition		 Sfntm1Mul/Sfntm1Mul
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfntm1Mul mutation (0 available); any Sfn mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland epithelium morphology ( J:159517 )
• multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from homozygous animals
• no apparent developmental or functional differences

integument
abnormal mammary gland epithelium morphology ( J:159517 )
• multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from homozygous animals
• no apparent developmental or functional differences




Genotype
MGI:4452139
cn2
Allelic
Composition		 Sfntm1Mul/Sfntm1Mul
Tg(MMTV-cre)7Mul/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfntm1Mul mutation (0 available); any Sfn mutation (15 available)
Tg(MMTV-cre)7Mul mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland epithelium morphology ( J:159517 )
• multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from mutant animals
• unaffected mammary ductal outgrowth
• threefold increase in the proliferative capacity of the luminal mammary epithelial cell
• unaffected rate of apoptotic cell death in mammary epithelial cells
• disrupted epithelial cell junctions at both the basal and apical layers shown by ZO-1 and E-Cadherin staining of isolated mammary epithelial cells in transwell monolayer cultures
• decreased percentage of polarized epithelial cells
• isolated mammary epithelial cells in 3D Matrigel cultures form filled lumens with depolarized epithelial growth, compared with the highly polarized acini derived from control cells
• dramatically reduced percentage of polarized cysts compared with wild-type controls in 3D Matrigel cultures
abnormal mammary gland duct morphology ( J:159517 )
• multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from mutant animals
• isolated mammary epithelial cells in 3D Matrigel cultures form filled lumens with depolarized epithelial growth, compared with the highly polarized acini derived from control cells

cellular
abnormal cell adhesion ( J:159517 )
• disrupted epithelial cell junctions at both the basal and apical layers shown by ZO-1 and E-Cadherin staining of isolated mammary epithelial cells in transwell monolayer cultures
• decreased percentage of polarized epithelial cells
increased cell proliferation ( J:159517 )
• threefold increase in the proliferative capacity of the luminal mammary epithelial cell

integument
abnormal mammary gland epithelium morphology ( J:159517 )
• multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from mutant animals
• unaffected mammary ductal outgrowth
• threefold increase in the proliferative capacity of the luminal mammary epithelial cell
• unaffected rate of apoptotic cell death in mammary epithelial cells
• disrupted epithelial cell junctions at both the basal and apical layers shown by ZO-1 and E-Cadherin staining of isolated mammary epithelial cells in transwell monolayer cultures
• decreased percentage of polarized epithelial cells
• isolated mammary epithelial cells in 3D Matrigel cultures form filled lumens with depolarized epithelial growth, compared with the highly polarized acini derived from control cells
• dramatically reduced percentage of polarized cysts compared with wild-type controls in 3D Matrigel cultures
abnormal mammary gland duct morphology ( J:159517 )
• multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from mutant animals
• isolated mammary epithelial cells in 3D Matrigel cultures form filled lumens with depolarized epithelial growth, compared with the highly polarized acini derived from control cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory