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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sfntm1Mul
targeted mutation 1, William J Muller
MGI:4452136
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sfntm1Mul/Sfntm1Mul involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:4452137
cn2
 		Sfntm1Mul/Sfntm1Mul
Tg(MMTV-cre)7Mul/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:4452139


Genotype
MGI:4452137
hm1
Allelic
Composition		 Sfntm1Mul/Sfntm1Mul
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfntm1Mul mutation (0 available); any Sfn mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland epithelium morphology ( J:159517 )
• multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from homozygous animals
• no apparent developmental or functional differences

integument
abnormal mammary gland epithelium morphology ( J:159517 )
• multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from homozygous animals
• no apparent developmental or functional differences




Genotype
MGI:4452139
cn2
Allelic
Composition		 Sfntm1Mul/Sfntm1Mul
Tg(MMTV-cre)7Mul/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfntm1Mul mutation (0 available); any Sfn mutation (15 available)
Tg(MMTV-cre)7Mul mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland epithelium morphology ( J:159517 )
• multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from mutant animals
• unaffected mammary ductal outgrowth
• threefold increase in the proliferative capacity of the luminal mammary epithelial cell
• unaffected rate of apoptotic cell death in mammary epithelial cells
• disrupted epithelial cell junctions at both the basal and apical layers shown by ZO-1 and E-Cadherin staining of isolated mammary epithelial cells in transwell monolayer cultures
• decreased percentage of polarized epithelial cells
• isolated mammary epithelial cells in 3D Matrigel cultures form filled lumens with depolarized epithelial growth, compared with the highly polarized acini derived from control cells
• dramatically reduced percentage of polarized cysts compared with wild-type controls in 3D Matrigel cultures
abnormal mammary gland duct morphology ( J:159517 )
• multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from mutant animals
• isolated mammary epithelial cells in 3D Matrigel cultures form filled lumens with depolarized epithelial growth, compared with the highly polarized acini derived from control cells

cellular
abnormal cell adhesion ( J:159517 )
• disrupted epithelial cell junctions at both the basal and apical layers shown by ZO-1 and E-Cadherin staining of isolated mammary epithelial cells in transwell monolayer cultures
• decreased percentage of polarized epithelial cells
increased cell proliferation ( J:159517 )
• threefold increase in the proliferative capacity of the luminal mammary epithelial cell

integument
abnormal mammary gland epithelium morphology ( J:159517 )
• multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from mutant animals
• unaffected mammary ductal outgrowth
• threefold increase in the proliferative capacity of the luminal mammary epithelial cell
• unaffected rate of apoptotic cell death in mammary epithelial cells
• disrupted epithelial cell junctions at both the basal and apical layers shown by ZO-1 and E-Cadherin staining of isolated mammary epithelial cells in transwell monolayer cultures
• decreased percentage of polarized epithelial cells
• isolated mammary epithelial cells in 3D Matrigel cultures form filled lumens with depolarized epithelial growth, compared with the highly polarized acini derived from control cells
• dramatically reduced percentage of polarized cysts compared with wild-type controls in 3D Matrigel cultures
abnormal mammary gland duct morphology ( J:159517 )
• multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from mutant animals
• isolated mammary epithelial cells in 3D Matrigel cultures form filled lumens with depolarized epithelial growth, compared with the highly polarized acini derived from control cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory