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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Wlstm1.1Lan
targeted mutation 1.1, Richard A Lang
MGI:4452362
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tg(KRT5-rtTA)#Glk/0
Tg(tetO-cre)1Jaw/0
Wlstm1.1Lan/Wlstm1.1Lan
involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:5538309
cn2
Tg(Krt1-15-cre/PGR*)22Cot/0
Wlstm1.1Lan/Wlstm1.1Lan
involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:5538317
cn3
Wlstm1.1Lan/Wlstm1.1Lan
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S/SvEv * C57BL/6J * CBA/J * SJL MGI:4838405
cn4
Wlstm1.1Lan/Wlstm1.1Lan
Tg(Pdx1-cre)6Tuv/0
involves: 129S/SvEv * FVB/N * SJL MGI:4838406
cn5
Wlstm1.1Lan/Wlstm1.1Lan
Tg(EIIa-cre)C5379Lmgd/0
involves: 129S/SvEv * FVB/N * SJL MGI:4838404


Genotype
MGI:5538309
cn1
Allelic
Composition
Tg(KRT5-rtTA)#Glk/0
Tg(tetO-cre)1Jaw/0
Wlstm1.1Lan/Wlstm1.1Lan
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT5-rtTA)#Glk mutation (0 available)
Tg(tetO-cre)1Jaw mutation (6 available)
Wlstm1.1Lan mutation (1 available); any Wls mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• in P60 animals, hair follicle structures are retained in absence of external hair, but display abnormalities including cyst formation
• cre induction at P4 causes hair follicle regression by P14 without loss of bulge stem cell markers
• when doxycline induction is performed from P4 to P18, epidermis exhibits increased proliferation as well as expanded expression of basal and suprabasal markers and hyperproliferation markers
• when doxycline induction is performed from P4 to P18, enlargement of intercellular spaces and some cell membrane protrusions are observed in some areas of mutant skins at P60
• defects of the interfollicular epidermis similar to those observed in conditional Ctnnb1 mutants are seen in induced mutants

immune system
• with doxycycline induction from P4-P18, mast cell number in the dermis is increased at P60

hematopoietic system
• with doxycycline induction from P4-P18, mast cell number in the dermis is increased at P60




Genotype
MGI:5538317
cn2
Allelic
Composition
Tg(Krt1-15-cre/PGR*)22Cot/0
Wlstm1.1Lan/Wlstm1.1Lan
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Krt1-15-cre/PGR*)22Cot mutation (2 available)
Wlstm1.1Lan mutation (1 available); any Wls mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• hyperproliferation is not observed in the epidermis with RU486 treatment from P20-P27




Genotype
MGI:4838405
cn3
Allelic
Composition
Wlstm1.1Lan/Wlstm1.1Lan
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S/SvEv * C57BL/6J * CBA/J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Wlstm1.1Lan mutation (1 available); any Wls mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• mutant mice exhibit a shortened anteroposterior axis
• mutant phenotype is obvious as early as E9.5 due to the presence of a shortened neural tube

nervous system
• mutant phenotype is obvious as early as E9.5 due to the presence of a shortened neural tube
• mutant mice exhibit no apparent isthmus
• at E12.5 a severely truncated forebrain
• absent midbrain
• at E10.5 verified deletion of regions of the metencephalon
• at E12.5




Genotype
MGI:4838406
cn4
Allelic
Composition
Wlstm1.1Lan/Wlstm1.1Lan
Tg(Pdx1-cre)6Tuv/0
Genetic
Background
involves: 129S/SvEv * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pdx1-cre)6Tuv mutation (3 available)
Wlstm1.1Lan mutation (1 available); any Wls mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands




Genotype
MGI:4838404
cn5
Allelic
Composition
Wlstm1.1Lan/Wlstm1.1Lan
Tg(EIIa-cre)C5379Lmgd/0
Genetic
Background
involves: 129S/SvEv * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(EIIa-cre)C5379Lmgd mutation (4 available)
Wlstm1.1Lan mutation (1 available); any Wls mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at E8.5, 9 of 10 embryos are in the process of being reabsorbed

embryo
• germline homozygotes appear arrested at E6, they do not progress past the egg cylinder stage, and by morphological criteria lack mesoderm





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory