immune system
N |
• mice exhibit normal B cell development and class switch recombination to IgG1 following stimulation with LPS and IL4
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Allele Symbol Allele Name Allele ID |
Ightm4.1Mnz targeted mutation 4.1, Michel C Nussenzweig MGI:4452369 |
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Summary |
7 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice exhibit normal B cell development and class switch recombination to IgG1 following stimulation with LPS and IL4
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• I-SceI mediated class switch recombination in LPS- and IL4-stimulated B cells is decreased compared to similarly treated Aicdatm1Hon/Aicdatm1Hon Ightm3Mnz/Ightm4.1Mnz B cells
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• I-SceI mediated class switch recombination in LPS- and IL4-stimulated B cells is decreased compared to similarly treated Aicdatm1Hon/Aicdatm1Hon Ightm3Mnz/Ightm4.1Mnz B cells
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• following Rbbp8 depletion using short hairpin RNA, B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells
• treatment with a small molecular inhibitor of Mre11a or Wrn produces no effect on resection of microhomology at the junctions
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• following Rbbp8 depletion using short hairpin RNA, B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells
• treatment with a small molecular inhibitor of Mre11a or Wrn produces no effect on resection of microhomology at the junctions
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells
|
• B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• B cells exhibit normal resection and junctional microhomology
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• following Rbbp8 depletion using short hairpin RNA, B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells
|
• following Rbbp8 depletion using short hairpin RNA, B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells
|
• B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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