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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sbdstm1Dats
targeted mutation 1, David T Scadden
MGI:4452398
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Sbdstm1Dats/Sbdstm1Dats
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: C57BL/6 * CD-1 MGI:4452404


Genotype
MGI:4452404
cn1
Allelic
Composition
Sbdstm1Dats/Sbdstm1Dats
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background
involves: C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sbdstm1Dats mutation (0 available); any Sbds mutation (31 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice exhibit intrameduallry apoptosis of hematopoeitic progenitor cells unlike in wild-type mice
• micro-megakaryocytes
• but not neutropenia
• B cell and B cell progenitors are decreased in the bone marrow compared to in wild-type mice
• myeloid cell frequency is increased in the bone marrow compared to in wild-type mice

skeleton
• texture of mineralized is altered compared to in wild-type mice
• bone marrow vascularity is increased compared to in wild-type mice

cardiovascular system
• bone marrow vascularity is increased compared to in wild-type mice

immune system
• but not neutropenia
• B cell and B cell progenitors are decreased in the bone marrow compared to in wild-type mice
• myeloid cell frequency is increased in the bone marrow compared to in wild-type mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory