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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sbdstm1Dats
targeted mutation 1, David T Scadden
MGI:4452398
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sbdstm1Dats/Sbdstm1Dats
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 		involves: C57BL/6 * CD-1 MGI:4452404


Genotype
MGI:4452404
cn1
Allelic
Composition		 Sbdstm1Dats/Sbdstm1Dats
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sbdstm1Dats mutation (0 available); any Sbds mutation (31 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
impaired hematopoiesis ( J:158901 )
• mice exhibit intrameduallry apoptosis of hematopoeitic progenitor cells unlike in wild-type mice
abnormal megakaryocyte morphology ( J:158901 )
• micro-megakaryocytes
decreased lymphocyte cell number ( J:158901 )
• but not neutropenia
decreased B cell number ( J:158901 )
• B cell and B cell progenitors are decreased in the bone marrow compared to in wild-type mice
abnormal myeloid leukocyte morphology ( J:158901 )
• myeloid cell frequency is increased in the bone marrow compared to in wild-type mice

skeleton
abnormal bone structure ( J:158901 )
• texture of mineralized is altered compared to in wild-type mice
abnormal bone marrow morphology ( J:158901 )
• bone marrow vascularity is increased compared to in wild-type mice

cardiovascular system
abnormal cardiovascular system morphology ( J:158901 )
• bone marrow vascularity is increased compared to in wild-type mice

immune system
decreased lymphocyte cell number ( J:158901 )
• but not neutropenia
decreased B cell number ( J:158901 )
• B cell and B cell progenitors are decreased in the bone marrow compared to in wild-type mice
abnormal myeloid leukocyte morphology ( J:158901 )
• myeloid cell frequency is increased in the bone marrow compared to in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory