About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Prnp-ITM2B*)6Jckr
transgene insertion 6, Mathias Jucker
MGI:4452484
Summary 2 genotypes


Genotype
MGI:4452490
cx1
Allelic
Composition		 Tg(Prnp-ITM2B*)6Jckr/0
Tg(Thy1-APP)3Somm/0
Genetic
Background		 B6.Cg-Tg(Prnp-ITM2B*)6Jckr Tg(Thy1-APP)3Somm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-ITM2B*)6Jckr mutation (0 available)
Tg(Thy1-APP)3Somm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:159279 )
• at 13 months, mice exhibit a 70% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APP)3Somm mice

homeostasis/metabolism
amyloidosis ( J:159279 )
• mice exhibit an accumulation of Dan-amyloid in separate plaques from amyloid beta plaques
amyloid beta deposits ( J:159279 )
• at 13 months, mice exhibit a 70% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APP)3Somm mice




Genotype
MGI:4452493
tg2
Allelic
Composition		 Tg(Prnp-ITM2B*)6Jckr/0
Genetic
Background		 C57BL/6-Tg(Prnp-ITM2B*)6Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
amyloidosis ( J:159279 )
• at 12 months, mice exhibit a 3- to 4-fold increase in Tau lesions compared with Tg(Thy1-MAPT*P301S)2541Godt mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory