All Phenotypes Cldn2<tm1Muto> MGI Mouse

renal/urinary system phenotype ( J:159379 )

N	• no gross morphological malformations in kidney

increased urine calcium level ( J:159379 )

• increased fractional excretion of calcium with free access to water and food

increased urine sodium level ( J:159379 )

• increased fractional excretion of NaCl in response to the NaCl challenge (i.v. administration of 2% NaCl at 20 ml/kg per hour)

decreased urine osmolality ( J:159379 )

• decreased osmolality with free access to water and food

• normal daily water or food intake

• normal body weight

abnormal renal reabsorption ( J:159379 )

• increased transepithelial electrical resistance in proximal tubules

• increased (2.5-fold) in paracellular shunt resistance (RS) in proximal tubules

• transepithelial voltage deflects markedly toward the negative when abruptly chang the luminal perfusate to the low NaCl solution in isolated perfused S2 segments of proximal tubules

• reduced relative permeability of Na+ to Cl- (PNa/PCl) when abruptly chang the luminal perfusate to the low NaCl solution in isolated perfused S2 segments of proximal tubules

• lower relative permeabilities of the other cations (K+, Rb+, Na+, Li+ and choline+) in proximal tubules than those in wild-type

• normal relative permeabilities of the other anions

abnormal renal water reabsorption ( J:159379 )

• decreased net transepithelial reabsorption of water in proximal tubules

abnormal renal sodium reabsorption ( J:159379 )

• decreased net transepithelial reabsorption of NaCl in proximal tubules

polyuria ( J:159379 )

• increased daily urine volume with free access to water and food