All Phenotypes Tex19.1<tm1Hjc> MGI Mouse

prenatal lethality, incomplete penetrance ( J:159793 )

• fewer than expected mice are born

decreased male germ cell number ( J:159793 )

• by P20, male germ cells are reduced compared to in wild-type mice

abnormal seminiferous tubule morphology ( J:159793 )

• narrower than in wild-type mice

small testis ( J:159793 )

decreased testis weight ( J:159793 )

abnormal spermatogenesis ( J:159793 )

• mice exhibit variably defective spermatogenesis compared to in wild-type mice

• postmeiotic cells types are missing compared to in wild-type mice

• a few mice exhibit more severe defects in spermatogenesis compared with wild-type mice with agametic testes

oligozoospermia ( J:159793 )

• median epididymal sperm count is reduced compared to in wild-type mice

abnormal male meiosis ( J:159793 )

• mice exhibit impaired chromosome synapsis during male meiosis unlike wild-type mice

• univalent chromosomes in metaphase I indicate a defect in formation or maintenance of chiasmata in post-pachytene spermatocytes unlike in wild-type mice

reduced female fertility ( J:159793 )

decreased litter size ( J:159793 )

• in homozygous female mice compared with heterozygous female mice

abnormal male reproductive system physiology ( J:159793 )

• testes exhibit over-expression of endogenous retrotransposable elements compared to in wild-type mice

increased male germ cell apoptosis ( J:159793 )

• pachytene and metaphase I spermatocytes undergo apoptosis unlike in wild-type mice

• increases in apoptosis is observed at P19 to P22 and P29 to P31 but not at P16

reduced male fertility ( J:159793 )

• severe