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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arg1tm1.1Lky
targeted mutation 1.1, Richard M Locksley
MGI:4453214
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Arg1tm1.1Lky/Arg1tm1.1Lky involves: 129S4/SvJae * C57BL/6 MGI:4453215
cx2
 		Arg1tm1.1Lky/Arg1+
Tg(Sftpc-Chia)#Lky/0 		involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2 MGI:4453223


Genotype
MGI:4453215
hm1
Allelic
Composition		 Arg1tm1.1Lky/Arg1tm1.1Lky
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arg1tm1.1Lky mutation (2 available); any Arg1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:4453223
cx2
Allelic
Composition		 Arg1tm1.1Lky/Arg1+
Tg(Sftpc-Chia)#Lky/0
Genetic
Background		 involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arg1tm1.1Lky mutation (2 available); any Arg1 mutation (28 available)
Tg(Sftpc-Chia)#Lky mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased macrophage cell number ( J:122735 )
• greatly reduced numbers of acdtivated macrophage in mice challenged with chitin

hematopoietic system
decreased macrophage cell number ( J:122735 )
• greatly reduced numbers of acdtivated macrophage in mice challenged with chitin




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory