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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cldn16tm1.1Dmu
targeted mutation 1.1, Dominik Muller
MGI:4453303
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cldn16tm1.1Dmu/Cldn16tm1.1Dmu involves: 129 * BALB/cJ * C57BL/6 MGI:4453304


Genotype
MGI:4453304
hm1
Allelic
Composition
Cldn16tm1.1Dmu/Cldn16tm1.1Dmu
Genetic
Background
involves: 129 * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cldn16tm1.1Dmu mutation (0 available); any Cldn16 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• significantly elevated serum parathyroid hormone level
• a modest but significant reduction in serum magnesium in 6 weeks old mice
• no hypomagnesemia in serum at day 4
• normal serum calcium level
• hypercalciuria (3-fold increase) in 4 days old mice
• more severe (11-fold increase) in 6 weeks old mice
• normal urinary values for magnesium, sodium, potassium, chloride, and creatinine
• normal renal appearance and microscopic anatomy
• no renal calcifications in up to 11-mo-old adult mice
• reduction in calcium permeability in the isolated perfused thick ascending limb of Henle's loop from 16- to 17-wk-old mice
• significantly elevated serum calcitriol (1,25(OH)2D3) level
• a significantly lower urinary pH

renal/urinary system
• hypercalciuria (3-fold increase) in 4 days old mice
• more severe (11-fold increase) in 6 weeks old mice
• normal urinary values for magnesium, sodium, potassium, chloride, and creatinine
• normal renal appearance and microscopic anatomy
• no renal calcifications in up to 11-mo-old adult mice
• a significantly lower urinary pH
• significant reduction of the permeability to magnesium in the isolated perfused thick ascending limb of Henle's loop from 9- to 10-wk-old and 16- to 17-wk-old mice
• reduction in calcium permeability in the isolated perfused thick ascending limb of Henle's loop from 16- to 17-wk-old mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
renal hypomagnesemia 3 DOID:0060880 OMIM:248250
J:159706





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory