homeostasis/metabolism
• significantly elevated serum parathyroid hormone level
|
• a modest but significant reduction in serum magnesium in 6 weeks old mice
• no hypomagnesemia in serum at day 4
• normal serum calcium level
|
• hypercalciuria (3-fold increase) in 4 days old mice
• more severe (11-fold increase) in 6 weeks old mice
• normal urinary values for magnesium, sodium, potassium, chloride, and creatinine
• normal renal appearance and microscopic anatomy
• no renal calcifications in up to 11-mo-old adult mice
|
• reduction in calcium permeability in the isolated perfused thick ascending limb of Henle's loop from 16- to 17-wk-old mice
|
• significantly elevated serum calcitriol (1,25(OH)2D3) level
|
• a significantly lower urinary pH
|
renal/urinary system
• hypercalciuria (3-fold increase) in 4 days old mice
• more severe (11-fold increase) in 6 weeks old mice
• normal urinary values for magnesium, sodium, potassium, chloride, and creatinine
• normal renal appearance and microscopic anatomy
• no renal calcifications in up to 11-mo-old adult mice
|
• a significantly lower urinary pH
|
• significant reduction of the permeability to magnesium in the isolated perfused thick ascending limb of Henle's loop from 9- to 10-wk-old and 16- to 17-wk-old mice
|
• reduction in calcium permeability in the isolated perfused thick ascending limb of Henle's loop from 16- to 17-wk-old mice
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
renal hypomagnesemia 3 | DOID:0060880 |
OMIM:248250 |
J:159706 |