Phenotypes associated with this allele

• Allele Symbol: Lhx2^tm1Lcar
• Allele Name: targeted mutation 1, Leif Carlsson
• Allele ID: MGI:4453327
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lhx2^tm1Lcar/Lhx2^tm1Lcar	involves: 129/Sv * C57BL/6	MGI:4453350

Genotype
MGI:4453350

hm1

• Allelic Composition: Lhx2^tm1Lcar/Lhx2^tm1Lcar
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hair follicle morphogenesis is hampered in Lhx2^tm1Lcar/Lhx2^tm1Lcar fetuses

vision/eye

anophthalmia ( J:159209 )

hematopoietic system

anemia ( J:159209 )

• less severe than in homozygous null embryos

integument

underdeveloped hair follicles ( J:159209 )

• developmentally arrested prior to the epithelial peg stage (Stage 4) compared to controls

decreased hair follicle number ( J:159209 )

• at E16.5 and E18.5, back skin contains fewer follicles compared to controls

• hair follicle density does not increase between E16.5 and E18.5 unlike in controls