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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lhx2tm1.1Lcar
targeted mutation 1.1, Leif Carlsson
MGI:4453328
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lhx2tm1.1Lcar/Lhx2tm1.1Lcar involves: 129P2/OlaHsd MGI:5311183
cn2
 		Lhx2tm1.1Lcar/Lhx2tm1.1Lcar
Tg(Lhx2-cre)1Lcar/0 		involves: 129P2/OlaHsd MGI:5311182
cn3
 		Lhx2tm1.1Lcar/Lhx2tm1Dra
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:4453345
cn4
 		Lhx2tm1.1Lcar/Lhx2tm1.1Lcar
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:4453347


Genotype
MGI:5311183
hm1
Allelic
Composition		 Lhx2tm1.1Lcar/Lhx2tm1.1Lcar
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx2tm1.1Lcar mutation (0 available); any Lhx2 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:176341 )
N
• eyes develop normally




Genotype
MGI:5311182
cn2
Allelic
Composition		 Lhx2tm1.1Lcar/Lhx2tm1.1Lcar
Tg(Lhx2-cre)1Lcar/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx2tm1.1Lcar mutation (0 available); any Lhx2 mutation (12 available)
Tg(Lhx2-cre)1Lcar mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal optic vesicle formation ( J:176341 )
• vesicle development is normal to E9.5, although the number of apoptotic cells is increased
• degeneration of the optic vesicle is detected at E11.5; by E12.5, all neural structures in the eye are absent with no detectable lens structure




Genotype
MGI:4453345
cn3
Allelic
Composition		 Lhx2tm1.1Lcar/Lhx2tm1Dra
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx2tm1.1Lcar mutation (0 available); any Lhx2 mutation (12 available)
Lhx2tm1Dra mutation (0 available); any Lhx2 mutation (12 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Hair follicles of tamoxifen-treated Lhx2tm1.1Lcar/Lhx2tm1Dra Tg(CAG-cre/Esr1*)5Amc/0 mice arrest during anagen progression and are unable to assemble a normal hair shaft

integument
abnormal hair growth ( J:159209 )
• most mice shaved and treated with Tamoxifen at 3 weeks of age do not regrow hair
abnormal hair cycle anagen phase ( J:159209 )
• unable to develop beyond Sub-stage III and assemble a normal hair shaft




Genotype
MGI:4453347
cn4
Allelic
Composition		 Lhx2tm1.1Lcar/Lhx2tm1.1Lcar
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx2tm1.1Lcar mutation (0 available); any Lhx2 mutation (12 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal hair growth ( J:159209 )
• most mice shaved and treated with Tamoxifen at 3 weeks of age do not regrow hair
abnormal hair cycle anagen phase ( J:159209 )
• unable to develop beyond Sub-stage III and assemble a normal hair shaft




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory