Phenotypes associated with this allele

• Allele Symbol: Trim32^tm1Hdin
• Allele Name: targeted mutation 1, Hao Ding
• Allele ID: MGI:4453461
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim32^tm1Hdin/Trim32^tm1Hdin	involves: 129S1/Sv	MGI:5425913

Genotype
MGI:5425913

hm1

• Allelic Composition: Trim32^tm1Hdin/Trim32^tm1Hdin
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Trim32^tm1Hdin/Trim32^tm1Hdin mice show delayed and impaired skeletal muscle regeneration

muscle

abnormal skeletal muscle morphology ( J:184218 )

• satellite cells are mis-localized in the interstitial space

centrally nucleated skeletal muscle fibers ( J:184218 )

• following cardiotoxin (CTX) injection

increased satellite cell number ( J:184218 )

• at 1 month but not 7 months

abnormal muscle physiology ( J:184218 )

• satellite cells exhibit a delay in the initiation of the myogenic differentiation program based on MyoD and Pax7 expression

delayed skeletal muscle regeneration ( J:184218 )

• delayed skeletal muscle regeneration following injection with cardiotoxin (CTX)

myopathy ( J:184218 )

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:184218 )

• following cardiotoxin (CTX) injection, mice exhibit impaired skeletal muscle regeneration, centrally nucleated skeletal muscle fibers and adipose-like cells in the muscle tissue compared with similarly treated control mice