About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dnajc10tm1Tiw
targeted mutation 1, Takao Iwawaki
MGI:4453462
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dnajc10tm1Tiw/Dnajc10tm1Tiw involves: 129S/SvEv * C57BL/6 MGI:4453471
cx2
Dnajc10tm1Tiw/Dnajc10tm1Tiw
Gt(ROSA)26Sortm1.2Tiw/Gt(ROSA)26Sor+
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 MGI:4453470


Genotype
MGI:4453471
hm1
Allelic
Composition
Dnajc10tm1Tiw/Dnajc10tm1Tiw
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnajc10tm1Tiw mutation (1 available); any Dnajc10 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• mice are fertile

homeostasis/metabolism
N
• mice exhibit normal blood biochemistry




Genotype
MGI:4453470
cx2
Allelic
Composition
Dnajc10tm1Tiw/Dnajc10tm1Tiw
Gt(ROSA)26Sortm1.2Tiw/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnajc10tm1Tiw mutation (1 available); any Dnajc10 mutation (44 available)
Gt(ROSA)26Sortm1.2Tiw mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• mice exhibit normal salivary gland morphology
• salivary glands exhibit an increase in luminescence compared to in Gt(ROSA)26Sortm1.2Tiw heterozygotes indicating increased endoplasmic reticulum (ER) stress
• however, mice exhibit normal production and secretion of salivary amylase

cellular
• mouse embryonic fibroblasts exhibit an increase in endoplasmic reticulum (ER) stress induced by amylase over-production compared with similarly treated wild-type cells
• however, over-expression of Dnajc10 mitigates ER stress induced by amylase over-production

digestive/alimentary system
• salivary glands exhibit an increase in luminescence compared to in Gt(ROSA)26Sortm1.2Tiw heterozygotes indicating increased endoplasmic reticulum (ER) stress
• however, mice exhibit normal production and secretion of salivary amylase





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory