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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnajc10tm1Tiw
targeted mutation 1, Takao Iwawaki
MGI:4453462
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dnajc10tm1Tiw/Dnajc10tm1Tiw involves: 129S/SvEv * C57BL/6 MGI:4453471
cx2
 		Dnajc10tm1Tiw/Dnajc10tm1Tiw
Gt(ROSA)26Sortm1.2Tiw/Gt(ROSA)26Sor+ 		involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 MGI:4453470


Genotype
MGI:4453471
hm1
Allelic
Composition		 Dnajc10tm1Tiw/Dnajc10tm1Tiw
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnajc10tm1Tiw mutation (1 available); any Dnajc10 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:159968 )
N
• mice are fertile

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:159968 )
N
• mice exhibit normal blood biochemistry




Genotype
MGI:4453470
cx2
Allelic
Composition		 Dnajc10tm1Tiw/Dnajc10tm1Tiw
Gt(ROSA)26Sortm1.2Tiw/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnajc10tm1Tiw mutation (1 available); any Dnajc10 mutation (44 available)
Gt(ROSA)26Sortm1.2Tiw mutation (0 available); any Gt(ROSA)26Sor mutation (992 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:159968 )
N
• mice exhibit normal salivary gland morphology
abnormal salivary gland physiology ( J:159968 )
• salivary glands exhibit an increase in luminescence compared to in Gt(ROSA)26Sortm1.2Tiw heterozygotes indicating increased endoplasmic reticulum (ER) stress
• however, mice exhibit normal production and secretion of salivary amylase

cellular
increased endoplasmic reticulum stress ( J:159968 )
• mouse embryonic fibroblasts exhibit an increase in endoplasmic reticulum (ER) stress induced by amylase over-production compared with similarly treated wild-type cells
• however, over-expression of Dnajc10 mitigates ER stress induced by amylase over-production

digestive/alimentary system
abnormal salivary gland physiology ( J:159968 )
• salivary glands exhibit an increase in luminescence compared to in Gt(ROSA)26Sortm1.2Tiw heterozygotes indicating increased endoplasmic reticulum (ER) stress
• however, mice exhibit normal production and secretion of salivary amylase




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory