Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^tm1.2Tiw
• Allele Name: targeted mutation 1.2, Takao Iwawaki
• Allele ID: MGI:4453463
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dnajc10^tm1Tiw/Dnajc10^tm1Tiw Gt(ROSA)26Sor^tm1.2Tiw/Gt(ROSA)26Sor^+	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6	MGI:4453470

Genotype
MGI:4453470

cx1

• Allelic Composition: Dnajc10^tm1Tiw/Dnajc10^tm1Tiw; Gt(ROSA)26Sor^tm1.2Tiw/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:159968 )

N • mice exhibit normal salivary gland morphology

abnormal salivary gland physiology ( J:159968 )

• salivary glands exhibit an increase in luminescence compared to in Gt(ROSA)26Sor^tm1.2Tiw heterozygotes indicating increased endoplasmic reticulum (ER) stress

• however, mice exhibit normal production and secretion of salivary amylase

cellular

increased endoplasmic reticulum stress ( J:159968 )

• mouse embryonic fibroblasts exhibit an increase in endoplasmic reticulum (ER) stress induced by amylase over-production compared with similarly treated wild-type cells

• however, over-expression of Dnajc10 mitigates ER stress induced by amylase over-production

digestive/alimentary system

abnormal salivary gland physiology ( J:159968 )

• salivary glands exhibit an increase in luminescence compared to in Gt(ROSA)26Sor^tm1.2Tiw heterozygotes indicating increased endoplasmic reticulum (ER) stress

• however, mice exhibit normal production and secretion of salivary amylase