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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kdm3atm1Jxu
targeted mutation 1, Jianming Xu
MGI:4453574
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kdm3atm1Jxu/Kdm3atm1Jxu involves: 129S6/SvEvTac * C57BL/6 MGI:4453575


Genotype
MGI:4453575
hm1
Allelic
Composition		 Kdm3atm1Jxu/Kdm3atm1Jxu
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm3atm1Jxu mutation (0 available); any Kdm3a mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Low testis weight and sperm count in Kdm3atm1Jxu/Kdm3atm1Jxu mice

reproductive system
increased male germ cell apoptosis ( J:159956 )
• group B germ cells (pachytene, diplotene, and secondary spermatocytes) and group C germ cells (round and elongating spermatids) exhibit a 5- and 10-fold higher rate of apoptosis, respectively, than in wild-type mice
oligozoospermia ( J:159956 )
• mice exhibit severe oligozoospermia with nearly no mature spermatozoa observed in the apical crypts of Sertoli cells or in the lumen of seminiferous tubules unlike in wild-type mice
abnormal spermatid morphology ( J:159956 )
• at steps 13 to 15, spermatids are short, irregular, and polygonal unlike in wild-type mice
abnormal spermiogenesis ( J:159956 )
• spermatid elongation is blocked unlike in wild-type mice

endocrine/exocrine glands

cellular
oligozoospermia ( J:159956 )
• mice exhibit severe oligozoospermia with nearly no mature spermatozoa observed in the apical crypts of Sertoli cells or in the lumen of seminiferous tubules unlike in wild-type mice
abnormal spermatid morphology ( J:159956 )
• at steps 13 to 15, spermatids are short, irregular, and polygonal unlike in wild-type mice
increased male germ cell apoptosis ( J:159956 )
• group B germ cells (pachytene, diplotene, and secondary spermatocytes) and group C germ cells (round and elongating spermatids) exhibit a 5- and 10-fold higher rate of apoptosis, respectively, than in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory