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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trip10tm1Sejc
targeted mutation 1, Seth J Corey
MGI:4453577
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trip10tm1Sejc/Trip10tm1Sejc involves: 129S1/Sv * 129X1/SvJ * ICR MGI:4453860


Genotype
MGI:4453860
hm1
Allelic
Composition		 Trip10tm1Sejc/Trip10tm1Sejc
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trip10tm1Sejc mutation (0 available); any Trip10 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
increased adipocyte glucose uptake ( J:159952 )
• insulin-stimulated glucose uptake is increased compared to in wild-type cells

homeostasis/metabolism
decreased circulating glucose level ( J:159952 )
• 20 minutes after glucose challenge, mice exhibit reduced blood glucose levels compared with similarly treated wild-type mice
• fasting mice exhibit decreased glucose serum levels compared with wild-type mice
• however, post-peak serum glucose levels during glucose challenge are normal

cellular
increased adipocyte glucose uptake ( J:159952 )
• insulin-stimulated glucose uptake is increased compared to in wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory