Phenotypes associated with this allele

• Allele Symbol: Il22^tm1Jcrd
• Allele Name: targeted mutation 1, Jean-Christophe Renauld
• Allele ID: MGI:4453827
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il22^tm1Jcrd/Il22^tm1Jcrd	B6.Cg-Il22^tm1Jcrd	MGI:4453829
hm2	Il22^tm1Jcrd/Il22^tm1Jcrd	Not Specified	MGI:5476735
cn3	Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Il22^tm1Jcrd/Il22^tm1Jcrd Tg(KRT14-cre)1Cgn/0	involves: C57BL/6 * DBA/2	MGI:5582491

Genotype
MGI:4453829

hm1

• Allelic Composition: Il22^tm1Jcrd/Il22^tm1Jcrd
• Genetic Background: B6.Cg-Il22^tm1Jcrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:155038 )

N • in contrast to expectations, EAE is inducible in the homozygous mice through immunization with MOG/CFA and mice developed disease similar to wild-type controls

Genotype
MGI:5476735

hm2

• Allelic Composition: Il22^tm1Jcrd/Il22^tm1Jcrd
• Genetic Background: Not Specified

hematopoietic system

decreased neutrophil cell number ( J:193548 )

• in the skin of IMQ-treated mice

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:193548 )

• mice are partial protected from IMQ (Aldara)-induced psoriasis with decreased ear swelling and numbers of neutrophils in the skin compared with wild-type mice

immune system

decreased neutrophil cell number ( J:193548 )

• in the skin of IMQ-treated mice

increased interleukin-17 secretion ( J:193548 )

• in the skin of IMQ-treated mice

Genotype
MGI:5582491

cn3

• Allelic Composition: Ikbkb^tm1Cgn/Ikbkb^tm1Cgn; Il22^tm1Jcrd/Il22^tm1Jcrd; Tg(KRT14-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * DBA/2

mortality/aging

postnatal lethality, incomplete penetrance ( J:208995 )

• before P9

integument

skin inflammation ( J:208995 )

• severe

skin lesions ( J:208995 )

• severe

immune system

skin inflammation ( J:208995 )

• severe