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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmem109tm1Yamt
targeted mutation 1, Tetsuo Yamazaki
MGI:4453832
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmem109tm1Yamt/Tmem109tm1Yamt B6.Cg-Tmem109tm1Yamt MGI:4453833


Genotype
MGI:4453833
hm1
Allelic
Composition		 Tmem109tm1Yamt/Tmem109tm1Yamt
Genetic
Background		 B6.Cg-Tmem109tm1Yamt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem109tm1Yamt mutation (0 available); any Tmem109 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte apoptosis ( J:157864 )
• unlike wild-type cells which undergo apoptosis, cells are sustained even after 8 h of suspension culture 17 hours after whole body irradiation about 2 fold more DP thymocytes are isolated indicating a resistance to radiation induced apoptosis
• however, in untreated mice no defects in thymocyte maturation are detected

immune system
decreased thymocyte apoptosis ( J:157864 )
• unlike wild-type cells which undergo apoptosis, cells are sustained even after 8 h of suspension culture 17 hours after whole body irradiation about 2 fold more DP thymocytes are isolated indicating a resistance to radiation induced apoptosis
• however, in untreated mice no defects in thymocyte maturation are detected

cellular
decreased thymocyte apoptosis ( J:157864 )
• unlike wild-type cells which undergo apoptosis, cells are sustained even after 8 h of suspension culture 17 hours after whole body irradiation about 2 fold more DP thymocytes are isolated indicating a resistance to radiation induced apoptosis
• however, in untreated mice no defects in thymocyte maturation are detected

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:157864 )
• unlike wild-type cells which undergo apoptosis, cells are sustained even after 8 h of suspension culture 17 hours after whole body irradiation about 2 fold more DP thymocytes are isolated indicating a resistance to radiation induced apoptosis
• however, in untreated mice no defects in thymocyte maturation are detected




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory