About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmem109tm1Yamt
targeted mutation 1, Tetsuo Yamazaki
MGI:4453832
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmem109tm1Yamt/Tmem109tm1Yamt B6.Cg-Tmem109tm1Yamt MGI:4453833


Genotype
MGI:4453833
hm1
Allelic
Composition		 Tmem109tm1Yamt/Tmem109tm1Yamt
Genetic
Background		 B6.Cg-Tmem109tm1Yamt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem109tm1Yamt mutation (0 available); any Tmem109 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte apoptosis ( J:157864 )
• unlike wild-type cells which undergo apoptosis, cells are sustained even after 8 h of suspension culture 17 hours after whole body irradiation about 2 fold more DP thymocytes are isolated indicating a resistance to radiation induced apoptosis
• however, in untreated mice no defects in thymocyte maturation are detected

immune system
decreased thymocyte apoptosis ( J:157864 )
• unlike wild-type cells which undergo apoptosis, cells are sustained even after 8 h of suspension culture 17 hours after whole body irradiation about 2 fold more DP thymocytes are isolated indicating a resistance to radiation induced apoptosis
• however, in untreated mice no defects in thymocyte maturation are detected

cellular
decreased thymocyte apoptosis ( J:157864 )
• unlike wild-type cells which undergo apoptosis, cells are sustained even after 8 h of suspension culture 17 hours after whole body irradiation about 2 fold more DP thymocytes are isolated indicating a resistance to radiation induced apoptosis
• however, in untreated mice no defects in thymocyte maturation are detected

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:157864 )
• unlike wild-type cells which undergo apoptosis, cells are sustained even after 8 h of suspension culture 17 hours after whole body irradiation about 2 fold more DP thymocytes are isolated indicating a resistance to radiation induced apoptosis
• however, in untreated mice no defects in thymocyte maturation are detected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/24/2024
MGI 6.24 		The Jackson Laboratory