Phenotypes associated with this allele

• Allele Symbol: Tg(MMTV-cre)FMam
• Allele Name: transgene insertion F, Lothar Hennighausen
• Allele ID: MGI:4453858
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ncoa6^tm1Jkr/Ncoa6^tm1Jkr Tg(MMTV-cre)FMam/?	involves: 129P2/OlaHsd * FVB	MGI:3810657
cn2	Etv6^tm3(NTRK3)Sho/Etv6^+ Tg(MMTV-cre)FMam/0	involves: 129S1/Sv * FVB/N	MGI:3772799
cn3	Ctnnd1^tm1Abre/Ctnnd1^tm1Abre Tg(MMTV-cre)FMam/0	involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/N	MGI:3618361
tg4	Tg(MMTV-cre)FMam/?	involves: FVB	MGI:4888637

Genotype
MGI:3810657

cn1

• Allelic Composition: Ncoa6^tm1Jkr/Ncoa6^tm1Jkr; Tg(MMTV-cre)FMam/?
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Retarded ductal branching of Ncoa6^tm1Jkr/Ncoa6^tm1Jkr Tg(MMTV-cre)FMam/? mammary glands during puberty

endocrine/exocrine glands

abnormal mammary gland development ( J:121207 )

♀ • defective mammopoiesis during puberty, pregnancy, and lactation

abnormal branching of the mammary ductal tree ( J:121207 )

♀ • mammary glands show a normal elongation of ducts but a decreased number of ductal branches and reduced density of ducts during puberty and long after puberty

♀ • ductal branching stimulated by direct estrogen treatment of ovariectomized females is attenuated in mutants

abnormal mammary gland growth during lactation ( J:121207 )

♀ • lactating mammary glands contain decreased numbers of lobuloalveoli with many adipoctyes

abnormal mammary gland growth during pregnancy ( J:121207 )

♀ • glands from females on the 15th day of pregnancy show impaired lobuloalveolar development with decreased density of alveoli

abnormal mammary duct terminal end bud morphology ( J:121207 )

♀ • slight increase in apoptosis is seen in the terminal end buds of mutant inguinal mammary glands

hypolactation ( J:121207 )

♀ • most pups from mutant litters die within 48 hours after birth with no milk in stomachs, however pups can be fostered by wild-type females, indicating inability to produce a sufficient amount of milk to nurse pups

reproductive system

abnormal mammary gland growth during pregnancy ( J:121207 )

♀ • glands from females on the 15th day of pregnancy show impaired lobuloalveolar development with decreased density of alveoli

integument

abnormal mammary gland development ( J:121207 )

♀ • defective mammopoiesis during puberty, pregnancy, and lactation

abnormal branching of the mammary ductal tree ( J:121207 )

♀ • mammary glands show a normal elongation of ducts but a decreased number of ductal branches and reduced density of ducts during puberty and long after puberty

♀ • ductal branching stimulated by direct estrogen treatment of ovariectomized females is attenuated in mutants

abnormal mammary gland growth during lactation ( J:121207 )

♀ • lactating mammary glands contain decreased numbers of lobuloalveoli with many adipoctyes

abnormal mammary gland growth during pregnancy ( J:121207 )

♀ • glands from females on the 15th day of pregnancy show impaired lobuloalveolar development with decreased density of alveoli

abnormal mammary duct terminal end bud morphology ( J:121207 )

♀ • slight increase in apoptosis is seen in the terminal end buds of mutant inguinal mammary glands

hypolactation ( J:121207 )

♀ • most pups from mutant litters die within 48 hours after birth with no milk in stomachs, however pups can be fostered by wild-type females, indicating inability to produce a sufficient amount of milk to nurse pups

Genotype
MGI:3772799

cn2

• Allelic Composition: Etv6^{tm3(NTRK3)Sho}/Etv6⁺; Tg(MMTV-cre)FMam/0
• Genetic Background: involves: 129S1/Sv * FVB/N

mortality/aging

premature death ( J:130323 )

• mice develop lethal myeloproliferative disease several weeks after birth

neoplasm

increased chronic myelocytic leukemia incidence ( J:130323 )

• mice develop lethal myeloproliferative disease several weeks after birth

Genotype
MGI:3618361

cn3

• Allelic Composition: Ctnnd1^tm1Abre/Ctnnd1^tm1Abre; Tg(MMTV-cre)FMam/0
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/N

mortality/aging

postnatal lethality, complete penetrance ( J:105283 )

• death occurs shortly after birth

digestive/alimentary system

abnormal major salivary gland morphology ( J:105283 )

• complete loss of exocrine acini in both the submandibular and sublingual glands

• both glands composed entirely of misshapen ducts

• foci present in which the epithelial structure of the ducts is completely disrupted

• foci expand from E14 to birth with all ducts eventually becoming occluded by large epithelial masses protruding into the lumen

• tube morphogenesis defective

abnormal sublingual gland morphology ( J:105283 )

abnormal submandibular gland morphology ( J:105283 )

abnormal submandibular gland physiology ( J:105283 )

• proliferating epithelial cells persist

increased submandibular gland apoptosis ( J:105283 )

• rates of apoptosis as much as 10X greater than controls

vision/eye

abnormal lacrimal gland morphology ( J:105283 )

• epithelia lack a prominent basal lamina

• collapsed lumina

• loss of cells and nuclear polarity

• cells with vacuolated cytoplasm

• poor cell-cell adhesion

endocrine/exocrine glands

abnormal major salivary gland morphology ( J:105283 )

• complete loss of exocrine acini in both the submandibular and sublingual glands

• both glands composed entirely of misshapen ducts

• foci present in which the epithelial structure of the ducts is completely disrupted

• foci expand from E14 to birth with all ducts eventually becoming occluded by large epithelial masses protruding into the lumen

• tube morphogenesis defective

abnormal sublingual gland morphology ( J:105283 )

abnormal submandibular gland morphology ( J:105283 )

abnormal submandibular gland physiology ( J:105283 )

• proliferating epithelial cells persist

increased submandibular gland apoptosis ( J:105283 )

• rates of apoptosis as much as 10X greater than controls

abnormal lacrimal gland morphology ( J:105283 )

• epithelia lack a prominent basal lamina

• collapsed lumina

• loss of cells and nuclear polarity

• cells with vacuolated cytoplasm

• poor cell-cell adhesion

cellular

increased submandibular gland apoptosis ( J:105283 )

• rates of apoptosis as much as 10X greater than controls

Genotype
MGI:4888637

tg4

• Allelic Composition: Tg(MMTV-cre)FMam/?
• Genetic Background: involves: FVB

endocrine/exocrine glands

abnormal mammary gland growth during lactation ( J:168531 )

♀ • mammary gland development checked at the end of lactation was highly variable among mice

♀ • cre expression as determined using Gt(ROSA)26Sor^tm1Sor as a reporter is detected in new born females

integument

abnormal mammary gland growth during lactation ( J:168531 )

♀ • mammary gland development checked at the end of lactation was highly variable among mice

♀ • cre expression as determined using Gt(ROSA)26Sor^tm1Sor as a reporter is detected in new born females

cellular

maternal effect ( J:168531 )

• none of 56 pups from 7 mothers survive to weaning