Analysis Tools
growth/size/body
|
• 16% reduction in body weight of males at 23 weeks of age and 23% reduction in females at 6 months of age
• mice 6 months of older on average weigh only 70% of controls
|
adipose tissue
|
• reduction in the thickness of the dermal adipose tissue (above the panniculus carnosus)
• reduction in cutaneous adipose tissue
|
|
• dermal adipocytes are reduced in size
|
|
• reduction of epididymal white adipose tissue
|
|
• mice show greatly reduced perigonadal white adipose tissue
|
endocrine/exocrine glands
|
• by P10 at the latest, sebaceous hypertrophy is apparent in the skin and persists thereafter, regardless of the phase of hair cycle
|
|
• proliferating cell nuclear antigen staining of catagen skin shows many more proliferating sebaceous precursors per gland in the skin
|
cardiovascular system
|
• juvenile mice exhibit prominent dilated blood vessels in their ears
|
integument
|
• reduction in the thickness of the dermal adipose tissue (above the panniculus carnosus)
• reduction in cutaneous adipose tissue
|
|
• by P10 at the latest, sebaceous hypertrophy is apparent in the skin and persists thereafter, regardless of the phase of hair cycle
|
|
• proliferating cell nuclear antigen staining of catagen skin shows many more proliferating sebaceous precursors per gland in the skin
|
|
• by 4 months of age, mice develop alopecia and inflammatory lesions in areas with less hair, areas prone to grooming/scratching, and in the upper chest and antecubital areas
• ear thickness is greater
• bone marrow reconstitution experiments indicate that early-onset skin phenotypes are not caused by immune defects
|
|
• skin exhibits scales that resemble seborrheic dermatitis
|
|
• mice exhibit extensive diffuse hair loss by P18 when the dorsal skin enters the quiescent phase of the hair cycle
• hair grows back during the subsequent anagen growth phase indicating recurrent alopecia, but hair coat remains unkempt and appears greasy and patches of regrown hair have a vellus-like appearance and lack pigmentation
|
|
• pups appear normal at birth but show an unkempt hair coat by 2 weeks after birth
|
greasy coat
(
J:210832
)
|
• hair shafts show breakage and lack of club hair when gently pulled, indicating brittle hair shafts
|
|
• pilary canal is greatly enlarged
|
|
• loss of most vibrissae
|
|
• increase in dermal thickness with an inflammatory infiltrate consisting of neutrophils, lymphocytes, and monocytes in affected skin
• dermal layer already appears thicker at P10
|
|
• in the inflammatory skin lesions
|
|
• diffuse orthokeratotic hyperkeratosis is seen in the skin by P10
|
|
• in the inflammatory skin lesions
|
|
• in the inflammatory skin lesions
|
acanthosis
(
J:210832
)
|
• occasional foci of acanthosis are seen at P10
|
|
• skin shows mild epidermal hyperplasia
|
skin lesions
(
J:210832
)
|
• mice develop inflammatory skin lesions, showing redness of the muzzle, upper chest, and antecubital areas, red, scaly eczematous lesions on the muzzle, periorbital swelling
|
|
• skin ulcerations on the upper chest in areas of alopecia
• ulcers show diffuse monocytic and lymphocytic dermal infiltrate
|
immune system
|
• by 4 months of age, mice develop alopecia and inflammatory lesions in areas with less hair, areas prone to grooming/scratching, and in the upper chest and antecubital areas
• ear thickness is greater
• bone marrow reconstitution experiments indicate that early-onset skin phenotypes are not caused by immune defects
|
|
• skin exhibits scales that resemble seborrheic dermatitis
|
