Phenotypes associated with this allele

• Allele Symbol: Megf10^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4454190
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Megf10^tm1(KOMP)Vlcg/Megf10^tm1(KOMP)Vlcg	C57BL/6N-Megf10^tm1(KOMP)Vlcg	MGI:5792947
ht2	Megf10^tm1(KOMP)Vlcg/Megf10^+	C57BL/6N-Megf10^tm1(KOMP)Vlcg	MGI:5792949

Genotype
MGI:5792947

hm1

• Allelic Composition: Megf10^{tm1(KOMP)Vlcg}/Megf10^{tm1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Megf10^{tm1(KOMP)Vlcg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased hindbrain apoptosis ( J:231811 )

• increase in apoptotic cells in the developing P7 cerebellum but not in adult cerebellum

nervous system

increased hindbrain apoptosis ( J:231811 )

• increase in apoptotic cells in the developing P7 cerebellum but not in adult cerebellum

abnormal cerebellum morphology ( J:231811 )

• increase in apoptotic cells in the developing P7 cerebellum but not in adult cerebellum

abnormal astrocyte physiology ( J:231811 )

• cultured astrocytes show impaired engulfment of UV-irradiated apoptotic MEFs, with an approximate 65% reduction in engulfment compared to wild-type astrocytes indicating impaired phagocytosis of apoptotic cells

Genotype
MGI:5792949

ht2

• Allelic Composition: Megf10^{tm1(KOMP)Vlcg}/Megf10⁺
• Genetic Background: C57BL/6N-Megf10^{tm1(KOMP)Vlcg}

cellular

increased hindbrain apoptosis ( J:231811 )

• increase in apoptotic cells specifically in the cerebellum at P7 but not in the adult cerebellum

nervous system

increased hindbrain apoptosis ( J:231811 )

• increase in apoptotic cells specifically in the cerebellum at P7 but not in the adult cerebellum

abnormal cerebellum morphology ( J:231811 )

• increase in apoptotic cells specifically in the cerebellum at P7 but not in the adult cerebellum

abnormal astrocyte physiology ( J:231811 )

• cultured astrocytes show impaired engulfment of UV-irradiated apoptotic MEFs, with an approximate 60% reduction in engulfment compared to wild-type astrocytes indicating impaired phagocytosis of apoptotic cells