mortality/aging
• born at a lower than expected Mendelian frequency
|
growth/size/body
hematopoietic system
• 40% lower thymocyte numbers
|
• increase in the ratios of CD4SP thymocytes to CD8SP thymocytes and of CD4+ to CD8+CD3+ lymph node T cells
|
• 50% lower splenocyte numbers
|
immune system
• 40% lower thymocyte numbers
|
• increase in the ratios of CD4SP thymocytes to CD8SP thymocytes and of CD4+ to CD8+CD3+ lymph node T cells
|
• 50% lower splenocyte numbers
|
endocrine/exocrine glands
• 40% lower thymocyte numbers
|