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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Patz1tm1.1Welm
targeted mutation 1.1, Wilfried Ellmeier
MGI:4454313
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Patz1tm1.1Welm/Patz1tm1.1Welm involves: 129P2/OlaHsd MGI:4454314
hm2
Patz1tm1.1Welm/Patz1tm1.1Welm involves: 129P2/OlaHsd * C57BL/6 MGI:4454317
cx3
Rr100tm2.1Welm/Rr100tm2.1Welm
Patz1tm1.1Welm/Patz1tm1.1Welm
involves: 129P2/OlaHsd * C57BL/6 MGI:4454318
cx4
Patz1tm1.1Welm/Patz1tm1.1Welm
Tg(TcraTcrb)1100Mjb/0
involves: 129P2/OlaHsd * C57BL/6 MGI:4454321
cx5
Patz1tm1.1Welm/Patz1tm1.1Welm
Tg(TcraTcrb)425Cbn/0
involves: C57BL/6 MGI:4454319


Genotype
MGI:4454314
hm1
Allelic
Composition
Patz1tm1.1Welm/Patz1tm1.1Welm
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Patz1tm1.1Welm mutation (0 available); any Patz1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• born at a lower than expected Mendelian frequency

growth/size/body

hematopoietic system
• 40% lower thymocyte numbers
• increase in the ratios of CD4SP thymocytes to CD8SP thymocytes and of CD4+ to CD8+CD3+ lymph node T cells
• 50% lower splenocyte numbers

immune system
• 40% lower thymocyte numbers
• increase in the ratios of CD4SP thymocytes to CD8SP thymocytes and of CD4+ to CD8+CD3+ lymph node T cells
• 50% lower splenocyte numbers

endocrine/exocrine glands
• 40% lower thymocyte numbers




Genotype
MGI:4454317
hm2
Allelic
Composition
Patz1tm1.1Welm/Patz1tm1.1Welm
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Patz1tm1.1Welm mutation (0 available); any Patz1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• viability is much lower when mice are backcrossed onto a C57BL/6 background




Genotype
MGI:4454318
cx3
Allelic
Composition
Rr100tm2.1Welm/Rr100tm2.1Welm
Patz1tm1.1Welm/Patz1tm1.1Welm
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Patz1tm1.1Welm mutation (0 available); any Patz1 mutation (55 available)
Rr100tm2.1Welm mutation (0 available); any Rr100 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• unlike mice with a wild-type copy of Patz, null mice have no defects in T cell differentiation




Genotype
MGI:4454321
cx4
Allelic
Composition
Patz1tm1.1Welm/Patz1tm1.1Welm
Tg(TcraTcrb)1100Mjb/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Patz1tm1.1Welm mutation (0 available); any Patz1 mutation (55 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• include a much higher percentage of CD4 SP cells and a correspondingly smaller CD8 SP population

immune system
• include a much higher percentage of CD4 SP cells and a correspondingly smaller CD8 SP population




Genotype
MGI:4454319
cx5
Allelic
Composition
Patz1tm1.1Welm/Patz1tm1.1Welm
Tg(TcraTcrb)425Cbn/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Patz1tm1.1Welm mutation (0 available); any Patz1 mutation (55 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• slightly higher percentage of CD4+ T cells and correspondingly lower frequency of CD8+ T

immune system
• slightly higher percentage of CD4+ T cells and correspondingly lower frequency of CD8+ T





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory