cellular
• decrease in the percentage of dividing CD8 T cells in response to stimulation by staphylococcal enterotoxin B pulsed A20 B cells or A20 B cells transfected with murine Pvr
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hematopoietic system
• decrease in the percentage of dividing CD8 T cells in response to stimulation by staphylococcal enterotoxin B pulsed A20 B cells or A20 B cells transfected with murine Pvr
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• NK cells do not appreciably kill B16F10 tumor cells
• however, the ability to kill YAC-1 cells is unimpaired
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immune system
• decrease in the percentage of dividing CD8 T cells in response to stimulation by staphylococcal enterotoxin B pulsed A20 B cells or A20 B cells transfected with murine Pvr
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• NK cells do not appreciably kill B16F10 tumor cells
• however, the ability to kill YAC-1 cells is unimpaired
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• significantly increased survival rates after LPS-induced endotoxicosis at 0.5 or 0.75 mg LPS/30 g levels
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neoplasm
• with lower tumor doses mice have significantly higher numbers of B16F10 lung metastases than do wild-type
• the injection of the mouse prostate carcinoma, RM-1, at all tumor doses inoculated, results in significantly higher numbers of RM-1 lung metastases than in wild-type
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• accelerated tumor growth is observed after subcutaneous injection of B16F10 compared to wild-type
• unlike wild-type mice, mice fail to reject the subcutaneous injection of a colon carcinoma cell line, MC38,that has been transfected with OVA
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• more lung metastases after injection of B16F10 melanoma cells into tail vein
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