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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox11tm1.1Vlf
targeted mutation 1.1, Veronique Lefebvre
MGI:4454340
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sox11tm1.1Vlf/Sox11tm1.1Vlf involves: 129 * C57BL/6 MGI:5285369
cn2
 		Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129 * C57BL/6 * C57BL/6J * CBA/J MGI:5285375
cn3
 		Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Prrx1-cre)1Cjt/0 		involves: 129 * C57BL/6 * SJL/J MGI:5285376
cn4
 		Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox12tm1.1Vlf/Sox12tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5285377
cn5
 		Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Dbh-icre)1Gsc/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:4454341


Genotype
MGI:5285369
hm1
Allelic
Composition		 Sox11tm1.1Vlf/Sox11tm1.1Vlf
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.1Vlf mutation (0 available); any Sox11 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:175338 )
• mice are indistinguishable from wild-type mice




Genotype
MGI:5285375
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (991 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Sox11tm1.1Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal pharyngeal arch development ( J:175338 )
• massive cell death in the branchial arches without a decrease in cell proliferation




Genotype
MGI:5285376
cn3
Allelic
Composition		 Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.1Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal limb mesenchyme morphology ( J:175338 )
• large increase in cell death in limb bud mesenchyme without a decrease in cell proliferation

embryo
abnormal limb mesenchyme morphology ( J:175338 )
• large increase in cell death in limb bud mesenchyme without a decrease in cell proliferation




Genotype
MGI:5285377
cn4
Allelic
Composition		 Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox12tm1.1Vlf/Sox12tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.1Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox12tm1.1Vlf mutation (0 available); any Sox12 mutation (8 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal limb mesenchyme morphology ( J:175338 )
• large increase in cell death in limb bud mesenchyme of mice transfected with a cre-expressing adenovirus without decrease in cell proliferation

embryo
abnormal limb mesenchyme morphology ( J:175338 )
• large increase in cell death in limb bud mesenchyme of mice transfected with a cre-expressing adenovirus without decrease in cell proliferation




Genotype
MGI:4454341
cn5
Allelic
Composition		 Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Dbh-icre)1Gsc/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.1Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
Tg(Dbh-icre)1Gsc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal Meibomian gland morphology ( J:157923 )
• Meibomian glands lack sympathetic innervation
blepharoptosis ( J:157923 )
• unable to fully open their eyes

nervous system
abnormal stellate ganglion morphology ( J:157923 )
• have only a small rudiment of the stellate ganglion
abnormal sympathetic neuron innervation pattern ( J:157923 )
• Meibomian glands, musculus tarsalis and arterioles of the eye lack sympathetic innervation
abnormal innervation pattern to muscle ( J:157923 )
• musculus tarsalis of the eyelid lacks sympathetic innervation

endocrine/exocrine glands
abnormal Meibomian gland morphology ( J:157923 )
• Meibomian glands lack sympathetic innervation

integument
abnormal Meibomian gland morphology ( J:157923 )
• Meibomian glands lack sympathetic innervation




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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory