All Phenotypes Sox11<tm1.1Vlf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sox11^tm1.1Vlf
targeted mutation 1.1, Veronique Lefebvre
MGI:4454340

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox11^tm1.1Vlf/Sox11^tm1.1Vlf	involves: 129 * C57BL/6	MGI:5285369
cn2	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Sox11^tm1.1Vlf/Sox11^tm1.1Vlf Sox4^tm1Vlf/Sox4^tm1Vlf H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129 * C57BL/6 * C57BL/6J * CBA/J	MGI:5285375
cn3	Sox11^tm1.1Vlf/Sox11^tm1.1Vlf Sox4^tm1Vlf/Sox4^tm1Vlf Tg(Prrx1-cre)1Cjt/0	involves: 129 * C57BL/6 * SJL/J	MGI:5285376
cn4	Sox11^tm1.1Vlf/Sox11^tm1.1Vlf Sox12^tm1.1Vlf/Sox12^tm1.1Vlf Sox4^tm1Vlf/Sox4^tm1Vlf	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5285377
cn5	Sox11^tm1.1Vlf/Sox11^tm1.1Vlf Sox4^tm1Vlf/Sox4^tm1Vlf Tg(Dbh-icre)1Gsc/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:4454341

Allelic Composition	Sox11^tm1.1Vlf/Sox11^tm1.1Vlf
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.1Vlf mutation (0 available); any Sox11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:175338 )

• mice are indistinguishable from wild-type mice

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Sox11^tm1.1Vlf/Sox11^tm1.1Vlf Sox4^tm1Vlf/Sox4^tm1Vlf H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (968 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Sox11^tm1.1Vlf mutation (0 available); any Sox11 mutation (14 available)
Sox4^tm1Vlf mutation (0 available); any Sox4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal pharyngeal arch development ( J:175338 )

• massive cell death in the branchial arches without a decrease in cell proliferation

Allelic Composition	Sox11^tm1.1Vlf/Sox11^tm1.1Vlf Sox4^tm1Vlf/Sox4^tm1Vlf Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129 * C57BL/6 * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.1Vlf mutation (0 available); any Sox11 mutation (14 available)
Sox4^tm1Vlf mutation (0 available); any Sox4 mutation (21 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal limb mesenchyme morphology ( J:175338 )

• large increase in cell death in limb bud mesenchyme without a decrease in cell proliferation

embryo

abnormal limb mesenchyme morphology ( J:175338 )

• large increase in cell death in limb bud mesenchyme without a decrease in cell proliferation

Allelic Composition	Sox11^tm1.1Vlf/Sox11^tm1.1Vlf Sox12^tm1.1Vlf/Sox12^tm1.1Vlf Sox4^tm1Vlf/Sox4^tm1Vlf
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11^tm1.1Vlf mutation (0 available); any Sox11 mutation (14 available)
Sox12^tm1.1Vlf mutation (0 available); any Sox12 mutation (8 available)
Sox4^tm1Vlf mutation (0 available); any Sox4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal limb mesenchyme morphology ( J:175338 )

• large increase in cell death in limb bud mesenchyme of mice transfected with a cre-expressing adenovirus without decrease in cell proliferation

embryo

abnormal limb mesenchyme morphology ( J:175338 )

• large increase in cell death in limb bud mesenchyme of mice transfected with a cre-expressing adenovirus without decrease in cell proliferation

Allelic Composition	Sox11^tm1.1Vlf/Sox11^tm1.1Vlf Sox4^tm1Vlf/Sox4^tm1Vlf Tg(Dbh-icre)1Gsc/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal Meibomian gland morphology ( J:157923 )

• Meibomian glands lack sympathetic innervation

blepharoptosis ( J:157923 )

• unable to fully open their eyes

nervous system

abnormal stellate ganglion morphology ( J:157923 )

• have only a small rudiment of the stellate ganglion

small superior cervical ganglion ( J:157923 )

• small rudiment

abnormal sympathetic neuron innervation pattern ( J:157923 )

• Meibomian glands, musculus tarsalis and arterioles of the eye lack sympathetic innervation

abnormal innervation pattern to muscle ( J:157923 )

• musculus tarsalis of the eyelid lacks sympathetic innervation

endocrine/exocrine glands

abnormal Meibomian gland morphology ( J:157923 )

• Meibomian glands lack sympathetic innervation

integument

abnormal Meibomian gland morphology ( J:157923 )

• Meibomian glands lack sympathetic innervation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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