About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sox11tm1.1Vlf
targeted mutation 1.1, Veronique Lefebvre
MGI:4454340
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sox11tm1.1Vlf/Sox11tm1.1Vlf involves: 129 * C57BL/6 MGI:5285369
cn2
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129 * C57BL/6 * C57BL/6J * CBA/J MGI:5285375
cn3
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Prrx1-cre)1Cjt/0
involves: 129 * C57BL/6 * SJL/J MGI:5285376
cn4
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox12tm1.1Vlf/Sox12tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5285377
cn5
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Dbh-icre)1Gsc/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:4454341


Genotype
MGI:5285369
hm1
Allelic
Composition
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.1Vlf mutation (0 available); any Sox11 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are indistinguishable from wild-type mice




Genotype
MGI:5285375
cn2
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Sox11tm1.1Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• massive cell death in the branchial arches without a decrease in cell proliferation




Genotype
MGI:5285376
cn3
Allelic
Composition
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129 * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.1Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• large increase in cell death in limb bud mesenchyme without a decrease in cell proliferation

embryo
• large increase in cell death in limb bud mesenchyme without a decrease in cell proliferation




Genotype
MGI:5285377
cn4
Allelic
Composition
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox12tm1.1Vlf/Sox12tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.1Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox12tm1.1Vlf mutation (0 available); any Sox12 mutation (8 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• large increase in cell death in limb bud mesenchyme of mice transfected with a cre-expressing adenovirus without decrease in cell proliferation

embryo
• large increase in cell death in limb bud mesenchyme of mice transfected with a cre-expressing adenovirus without decrease in cell proliferation




Genotype
MGI:4454341
cn5
Allelic
Composition
Sox11tm1.1Vlf/Sox11tm1.1Vlf
Sox4tm1Vlf/Sox4tm1Vlf
Tg(Dbh-icre)1Gsc/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.1Vlf mutation (0 available); any Sox11 mutation (15 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (23 available)
Tg(Dbh-icre)1Gsc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• Meibomian glands lack sympathetic innervation
• unable to fully open their eyes

nervous system
• have only a small rudiment of the stellate ganglion
• Meibomian glands, musculus tarsalis and arterioles of the eye lack sympathetic innervation
• musculus tarsalis of the eyelid lacks sympathetic innervation

endocrine/exocrine glands
• Meibomian glands lack sympathetic innervation

integument
• Meibomian glands lack sympathetic innervation





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory