Phenotypes associated with this allele

• Allele Symbol: Carm1^tm2.1Mtb
• Allele Name: targeted mutation 2.1, Mark T Bedford
• Allele ID: MGI:4454543
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Carm1^tm2.1Mtb/Carm1^tm2.1Mtb	involves: 129S4/SvJaeSor * 129S6/SvEvTac * Black Swiss	MGI:4454544

Genotype
MGI:4454544

hm1

• Allelic Composition: Carm1^tm2.1Mtb/Carm1^tm2.1Mtb
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small size of Carm1^tm2.1Mtb/Carm1^tm2.1Mtb fetuses

mortality/aging

neonatal lethality, complete penetrance ( J:159958 )

• mice die at birth

immune system

thymus hypoplasia ( J:159958 )

arrested T cell differentiation ( J:159958 )

• at the DN1 progenitor stage

adipose tissue

abnormal adipose tissue development ( J:159958 )

• E18.5 mice fail to express a marker of adipogenesis (Thrsp) unlike wild-type mice

growth/size/body

decreased fetal size ( J:159958 )

• at E18.5

hematopoietic system

thymus hypoplasia ( J:159958 )

arrested T cell differentiation ( J:159958 )

• at the DN1 progenitor stage

endocrine/exocrine glands

thymus hypoplasia ( J:159958 )