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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tie1tm1Geno
targeted mutation 1, Genoway
MGI:4454546
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tie1tm1Geno/Tie1tm1Geno involves: ICR MGI:4454552
cn2
Tie1tm1Geno/Tie1tm1Geno
Tg(ACTFLPe)9205Dym/0
involves: C57BL/6 * ICR * SJL MGI:4454553


Genotype
MGI:4454552
hm1
Allelic
Composition
Tie1tm1Geno/Tie1tm1Geno
Genetic
Background
involves: ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tie1tm1Geno mutation (0 available); any Tie1 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• at E15.5, mice exhibit edema unlike wild-type mice
• however, flp mediated recombination to remove the neo cassette restores wild-type phenotype

immune system
• at E15.5, mice exhibit abnormally patterned lymph sacs compared with wild-type mice as determined by marker expression
• however, flp mediated recombination to remove the neo cassette restores lymphangiogenesis




Genotype
MGI:4454553
cn2
Allelic
Composition
Tie1tm1Geno/Tie1tm1Geno
Tg(ACTFLPe)9205Dym/0
Genetic
Background
involves: C57BL/6 * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTFLPe)9205Dym mutation (7 available)
Tie1tm1Geno mutation (0 available); any Tie1 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice exhibit normal lymphangiogenesis





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory