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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il6ratm1Saj
targeted mutation 1, Simon A Jones
MGI:4454682
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il6ratm1Saj/Il6ratm1Saj involves: 129P2/OlaHsd * C57BL/6J MGI:4454772


Genotype
MGI:4454772
hm1
Allelic
Composition		 Il6ratm1Saj/Il6ratm1Saj
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6ratm1Saj mutation (2 available); any Il6ra mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive, alpha-beta T cell physiology ( J:159479 )
• CD4+ T cells are nonresponsive to IL6-induced Th17 development unlike wild-type cells

hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:159479 )
• CD4+ T cells are nonresponsive to IL6-induced Th17 development unlike wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory