Phenotypes associated with this allele

• Allele Symbol: Tg(KRT14-Il7)1Tsk
• Allele Name: transgene insertion 1, Thomas S Kupper
• Allele ID: MGI:4454778
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(KRT14-Il7)1Tsk/Tg(KRT14-Il7)1Tsk	FVB/N-Tg(KRT14-Il7)1Tsk	MGI:4829528
tg2	Tg(KRT14-Il7)1Tsk/Tg(KRT14-Il7)1Tsk	involves: C57BL/6 * FVB	MGI:4829529
tg3	Tg(KRT14-Il7)1Tsk/0	FVB/N-Tg(KRT14-Il7)1Tsk	MGI:4829525

Genotype
MGI:4829528

tg1

• Allelic Composition: Tg(KRT14-Il7)1Tsk/Tg(KRT14-Il7)1Tsk
• Genetic Background: FVB/N-Tg(KRT14-Il7)1Tsk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:42565 )

• majority of mice die at less than 4 weeks of age

immune system

skin inflammation ( J:42565 )

• biopsy indicates a dense dermal infiltrate of lymphocytes through the reticular and papillary dermis and extending into the epidermis

reproductive system

infertility ( J:42565 )

• surviving mice are infertile

growth/size/body

decreased body size ( J:42565 )

• runting is evident by 2-3 weeks of age

integument

skin inflammation ( J:42565 )

• biopsy indicates a dense dermal infiltrate of lymphocytes through the reticular and papillary dermis and extending into the epidermis

alopecia ( J:42565 )

• alopecia develops on dorsal trunk skin around 3 weeks of age

Genotype
MGI:4829529

tg2

• Allelic Composition: Tg(KRT14-Il7)1Tsk/Tg(KRT14-Il7)1Tsk
• Genetic Background: involves: C57BL/6 * FVB

mortality/aging

decreased survivor rate ( J:42565 )

• some mice do not survive to adulthood

reproductive system

infertility ( J:42565 )

• some mice are fertile

integument

alopecia ( J:42565 )

Genotype
MGI:4829525

tg3

• Allelic Composition: Tg(KRT14-Il7)1Tsk/0
• Genetic Background: FVB/N-Tg(KRT14-Il7)1Tsk

immune system

blepharitis ( J:42565 )

• eyelid inflammation visible after eyes are opened

skin inflammation ( J:42565 )

• ear skin exhibits dermal mononuclear cells with loosely associated agregates

hearing/vestibular/ear

thick ears ( J:42565 )

• increase in ear thickness

craniofacial

thick ears ( J:42565 )

• increase in ear thickness

vision/eye

blepharitis ( J:42565 )

• eyelid inflammation visible after eyes are opened

delayed eyelid opening ( J:42565 )

• delay of at least two day in opening eyes

integument

skin inflammation ( J:42565 )

• ear skin exhibits dermal mononuclear cells with loosely associated agregates

alopecia ( J:42565 )

• alopecia is visible on trunk

reddish skin ( J:42565 )

• erythema is visible on trunk

growth/size/body

thick ears ( J:42565 )

• increase in ear thickness